Adhesively luted, fiber-reinforced, composite-inlay, retained fixed-partial dentures can be a clinical alternative for the replacement of missing posterior teeth in selective situations. This type of restoration allows for satisfactory esthetics and reduced tooth preparation compared to a conventional, fixed-partial denture. This clinical report describes the use of a fiber-reinforced, composit...

Formulated as a least square problem under an constraint, sparse signal restoration is a discrete optimization problem, known to be NP complete. Classical algorithms include, by increasing cost and efficiency, matching pursuit (MP), orthogonal matching pursuit (OMP), orthogonal least squares (OLS), stepwise regression algorithms and the exhaustive search. We revisit the single most likely repla...

The authors performed a matched-paired study comparing 22 computer-assisted surgery (CAS)-unicompartmental knee replacement (UKR) revisions with a similar group of knee replacement revisions performed conventionally. The aim of the study was to assess differences in implants used in the revision, surgical time, limb alignment, joint line restoration, and procedure costs. In the conventional gro...

Dopamine-deficient (DD) mice cannot synthesize dopamine (DA) in dopaminergic neurons due to selective inactivation of the tyrosine hydroxylase gene in those neurons. These mice become hypoactive and hypophagic and die of starvation by 4 weeks of age. We used gene therapy to ascertain where DA replacement in the brain restores feeding and other behaviors in DD mice. Restoration of DA production ...

Currently available β-cell replacement therapies for patients with diabetes, including islet and pancreas transplantation, are largely successful in restoring normal glucose metabolism, but the scarcity of organ donors restricts their more widespread use. To solve this supply problem, several different strategies for achieving β-cell mass restoration are being pursued. These include the generat...

We describe a case of severe erythrocytosis caused by testosterone replacement therapy in a 66-year-old man affected with hypogonadotropic hypogonadism (HH) determining osteoporosis, resolved by switching to restoration therapy with clomiphene citrate. The patient complained fatigue, loss of libido and defective erections and a spontaneous vertebral fracture despite bisphosphonate therapy and v...

Composite resin restoration has been increasingly used in restorative dentistry with patient’s demands, and also composite resin materials as well as bonding agents have been developed continuously. Despite of these developments, several factors, such as inadequate form, wear, color mismatch, chipping or bulk fracture may still present concerns. In case of failure, the clinician must determine ...

Oral lichenoid reactions are considered variants of oral lichen planus and may be regarded as a disease by itself or as an exacerbation of an existing oral lichen planus by the presence of medication or dental materials. They represent a type IV hypersensitivity reaction and most commonly affect the oral mucosa in direct contact with an amalgam restoration. Oral lichenoid reactions can cause si...

After reading this article, the reader should be able to: • describe requirements that would lead to success with immediate implant placement and loading. • describe important surgical considerations to increase the survival of immediate implant restoration. • discuss advantages in the single appointment fabrication of computer-assisted designed and machined porcelain for implant restoration. •...