Recently developed optical techniques provide quantitative structural measurements of the retinal nerve fiber layer (RNFL). A complete interpretation of these measurements requires understanding of the optical properties of the RNFL. This paper gives a review of the polarization properties and relevant anatomy of the ocular tissues, followed by a thorough discussion of the optical properties of...

INTRODUCTION Peripapillary retinal nerve fiber layer (RNFL) thickness analysis is a subjective method of analysis of glaucomatous damage. As almost 50% of retinal ganglion cells are located in the macula, assessment of macular thickness can be an alternative method for diagnosis of glaucoma. OBJECTIVES To evaluate the changes in macular and retinal nerve fiber layer thickness in controls, gla...

Glaucoma is a chronic, progressive neurodegenerative disease. It is defined as chronic progressive optic neuropathy with typical optic disk and retinal nerve fiber layer (RNFL) changes with corresponding visual field defect. Intraocular pressure (IOP) is considered only a major risk factor and not a diagnostic criterion. At present, clinically visible RNFL defects are considered as the sensitiv...

BACKGROUND Identifying and assessing retinal nerve fiber layer defects are important for diagnosing and managing glaucoma. We aimed to investigate the effect of refractive correction error on retinal nerve fiber layer (RNFL) thickness measured with Spectralis spectral-domain optical coherence tomography (SD-OCT). MATERIAL AND METHODS We included 68 participants: 32 healthy (normal) and 36 glauc...

INTRODUCTION Measuring the thickness of the retinal nerve fiber layer is a potential method of recognizing axon loss prior to the visual field abnormality. OBJECTIVE To study normal individuals to quantify peripapillary retinal nerve fiber layer (RNFL) thickness in Asian Indian subjects. MATERIALS AND METHODS This was a prospective study of 150 normal subjects. Peripapillary RNFL was imaged...

Purpose To evaluate whether corneal confocal microscopy (CCM) detects axonal degeneration and whether this is associated with retinal nerve fiber degeneration and clinical disability in patients with multiple sclerosis (MS). Methods Twenty-five patients with MS and 25 healthy control subjects underwent CCM, optical coherence tomography (OCT), and assessment of neurological disability using th...

Glaucoma is an optic neuropathy that affects the ganglion cell complex in all its components: cell bodies, dendrites, and axons, the dendritic arbor being the first one damaged. This is the reason why the thickness of the ganglion cell and internal plexiform layers can be taken into account as an early predictor of the glaucomatous changes, along with the retinal nerve fiber layer (RNFL) thickn...

This prospective study was performed to measure the macular and the peripapillary retinal nerve fiber layer (RNFL) thicknesses using optical coherence tomography (OCT) in patients with anisometropic amblyopia. Thirty-one patients with hyperopic anisometropic amblyopia were included. The macular retinal thickness and the peripapillary RNFL thickness were measured using OCT. The mean refractive e...

PURPOSE The retinal nerve fiber layer (RNFL) exhibits linear birefringence due to the oriented cylindrical structure of ganglion cell axons. The birefringence (Deltan) depends on the density and composition of axonal organelles. The purpose of this study was to evaluate the distribution of birefringence around the optic nerve head (ONH) in normal subjects. METHODS Birefringence was calculated...

multiple sclerosis (ms) is the most prevalent disease caused by the inflammatory demyelinating process that causes progressive nervous system degeneration over the time. optical coherence tomography (oct) is a non-invasive optical imaging technology, which can measure the thickness of retinal nerve fiber layer as well as the diameter of the macula. the purpose of the study is evaluation oct fin...