نتایج جستجو برای: rgs
تعداد نتایج: 1331 فیلتر نتایج به سال:
Regulators of G protein signaling (RGS) proteins are potent negative modulators of G protein signaling and have been proposed as potential targets for small-molecule inhibitor development. We report a high-throughput time-resolved fluorescence resonance energy transfer screen to identify inhibitors of RGS4 and describe the first reversible small-molecule inhibitors of an RGS protein. Two closel...
Regulator of G protein signaling (RGS) proteins inhibit G protein signaling by activating Galpha GTPase activity, but the mechanisms that regulate RGS activity are not well understood. The mammalian R7 binding protein (R7BP) can interact with all members of the R7 family of RGS proteins, and palmitoylation of R7BP can target R7 RGS proteins to the plasma membrane in cultured cells. However, whe...
For the identification of regulators of G-protein signaling (RGS) modulators, previously, we developed a luciferase based yeast pheromone response (YPhR) assay to functionally investigate RGS4 (K.H. Young, Y. Wang, C. Bender, S. Ajit, F. Ramirez, A. Gilbert, B.W. Nieuwenhuijsen, in: D.P. Siderovski (Ed.), Meth. Enzymol. 389 Regulators of G_protein Signaling, Part A, 2004.). To extend the divers...
BACKGROUND Gene expression analyses demand appropriate reference genes (RGs) for normalization, in order to obtain reliable assessments. Ideally, RG expression levels should remain constant in all cells, tissues or experimental conditions under study. Housekeeping genes traditionally fulfilled this requirement, but they have been reported to be less invariant than expected; therefore, RGs shoul...
Mammalian regulator of G protein signaling (RGS) proteins are highly conserved within the RGS domain. Of amino acids that are universal, a serine residue at the C terminus of this domain has been described as the binding site in RGS7 for 14-3-3 proteins. However, studies with the related RGS3 indicate that the site of interaction is not within the RGS domain. We confirm that the interaction of ...
reproductive parameters and ovipositional preference of plutella xylostella were assessed on some mutant genotypes of canola (rgs 8-1, rgs 10-2, rgs 8-13, zar 9-9 and talaye 8-3) and their cultivars (rgs, zar, talaye) under greenhouse condition (21 ± 6 °c, 65 ± 10 rh and a photoperiod of 16l: 8d h). comparison of the reproductive parameters on rgs and its mutant genotypes revealed that mutant g...
CONTEXT Elite gymnasts are subjected to intense training, which may alter pubertal development. OBJECTIVE The objective of the investigation was to study the impact of gymnastics on pubertal development in rhythmic (RGs) and artistic gymnasts (AGs). DESIGN Evaluation of somatometric parameters, pubertal stage, and intensity of training in the competition field were studied. SETTING The st...
به منظور ارزیابی اثر تنش شوری بر ویژگی¬های جوانه¬زنی و برخی از خصوصیات مورفولوژیکی و فیزیولوژیکی آزمایشی در دانشکده کشاورزی دانشگاه فردوسی مشهد در سال 92-1391 به صورت فاکتوریل در قالب طرح کامل تصادفی درسه تکرار در دو مرحله آزمایشگاهی و گلخانه¬ای انجام شد. تیمار¬های آزمایشی مرحله اول شامل دو رقم کلزا (rgs, hyola)، 7 تیمار دمایی (5، 10، 15، 20، 25، 30، 35 و 40 درجه¬سانتی¬گراد) و 5 سطح شوری (0، 1،...
We have isolated an RGS-GAIP interacting protein that links RGS proteins to protein degradation. GIPN (GAIP interacting protein N terminus) is a 38-kDa protein with an N-terminal leucine-rich region, a central RING finger-like domain, and a putative C-terminal transmembrane domain. GIPN binds exclusively to RGS proteins of subfamily A, RGS-GAIP, RGSZ1, and RGSZ2. The N-terminal leucine-rich reg...
Regulator of G-protein signaling (RGS) proteins are strong modulators of G-protein-mediated pathways in the nervous system. One function of RGS proteins is to accelerate the activation-deactivation kinetics of G-protein-coupled inwardly rectifying potassium (GIRK) channels. The opening of GIRK channels reduces the firing rates of neurons. Recent studies indicate that RGS proteins also modulate ...
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