In humans, NH(3) transport across cell membranes is facilitated by the Rh (rhesus) family of proteins. Human Rh C glycoprotein (RhCG) forms a trimeric complex that plays an essential role in ammonia excretion and renal pH regulation. The X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport. Each monomer contains 12 transmembr...

Background . when transplantation of hematopoietic stem cells (HSC) is performing, it necessary to take into account the incompatibility donor and recipient in terms erythrocyte antigens order assess possibility immunological complications during HSC transfusion and/or graft engraftment (acute hemolysis, delayed etc.). The results serological research methods do not always allow identifying tru...

BACKGROUND The DEL blood type, a very weak D variant, is a major concern in the field of transfusion medicine because of its potential to cause anti-D alloimmunization. We investigated the molecular basis of serologically D-negative phenotypes, including the DEL type, and the distribution of other blood group systems in the Korean population using the recently developed multiplex ligation-depen...

Recent molecular studies on the Rh blood group system have shown that the Rh locus of each haploid RhD-positive chromosome is composed of two structural genes: RHD and RHCE, whereas the locus is made of a single gene (RHCE) on each haploid RhD-negative chromosome. We analyzed the presence or absence of the RHD gene in 130 Japanese RhD-negative donors using the PCR method. The RhD-negative pheno...

Vinylbenzoate-bridged diruthenium complexes (RHC=CH)(CO)(P(i)Pr(3))(2)Ru(mu-4-OOCC(6)H(4)-CH=CH)RuCl(CO)(P(i)Pr(3))(2) (R = Ph, 3a or CF(3), 3b) and vinylpyridine-bridged (eta(6)-p-cymene)Cl(2)Ru(mu-NC(5)H(4)-4-CH=CH)RuCl(CO)(P(i)Pr(3))(2) (3c) have been prepared from their monoruthenium precursors and investigated with respect to the sequence of the individual redox steps and electron delocali...

Evidence is presented that RHD, RHCE, and other RH genes, may be interesting candidates to consider when searching for the genetic basis of hair whorl rotation (i.e., clockwise or counterclockwise), handedness (i.e., right handed, left handed or ambidextrous), speech laterality (i.e., right brained or left brained), speech dyslexia (e.g., stuttering), sexual orientation (i.e., heterosexual, hom...