Linoleic acid hydroperoxide (LoaOOH) formed during free radical attack on long-chain unsaturated fatty acids is an important source of biomembrane damage and is implicated in the onset of atherosclerosis, hepatic diseases, and food rancidity. LoaOOH is toxic to wild-type Saccharomyces cerevisiae at a very low concentration (0.2 mM) relative to other peroxides. By using isogenic mutant strains, ...

Mitochondrial dysfunction has been implicated in the dopaminergic neurodegeneration, which characterizes Parkinson’s disease (PD). The activities of mitochondrial complexes I and IV were found to be reduced in the brains of PD patients (n = 4) as compared to age-matched controls (n = 4). This is tested in SH-SY5Y cell lines, transformed Rho0 cells, and in normal and PD cybrid cell lines. Cybrid...

Mitochondrial dysfunction has been implicated in the dopaminergic neurodegeneration, which characterizes Parkinson’s disease (PD). The activities of mitochondrial complexes I and IV were found to be reduced in the brains of PD patients (n = 4) as compared to age-matched controls (n = 4). This is tested in SH-SY5Y cell lines, transformed Rho0 cells, and in normal and PD cybrid cell lines. Cybrid...

The bidirectional reflectance parametric and semi-empirical Rahman-PintyVerstraete (RPV) model was inverted based on Bidirectional Reflectance Factor (BRF) measurements of 60 Fagus sylvatica L. leaves in the optical domain between 400 nm and 2,500 nm. This was accomplished using data retrieved from the Compact Laboratory Spectro-Goniometer (CLabSpeG) with an azimuth and zenith angular step of 3...

Background Mitochondrial reprogramming has emerged as a hallmark of cancer pathobiology. Although it is believed this reprogramming is essential for cancer cells to thrive, how it supports cancer pathobiology is unclear. We previously generated colonic ρ0 (rho0) cells with reduced mitochondrial energy function and acquired their transcriptional signature. Here, we utilized a bioinformatics appr...

We use the ~370 square degrees data from MWISP CO survey to study vertical distribution of molecular clouds (MCs) toward tangent points in region l=[16,52]deg and |b|<5.1deg. The disk consists two components with layer thickness (FWHM) ~85pc ~280pc, respectively. In inner Galaxy, mass thin is dominant, while traced by discrete MCs weak emission thick probably <10% whole disk. For gas disk, we i...

Heme oxygenase overexpression or exogenous carbon monoxide (CO) protects against hepatocyte apoptosis and fulminant hepatitis. The prevention of hepatocyte apoptosis by CO has been shown to require activation of NF-kappaB. The purpose of these investigations was to determine the mechanism of CO-induced hepatocyte NF-kappaB activation and protection against apoptosis. Primary rat or mouse hepato...