OBJECTIVE Treatment of latent TB infection (LTBI) in high-risk populations has been identified as a priority activity for reducing TB incidence. Treatment completion rates are usually far from the 80% target. The objective of this study was to evaluate the proportion of individuals who obtained enough medication for standard LTBI treatment. METHODS Using the Régie de l'assurance maladie du Qu...

Twelve N-substituted-glycinyl triazolyl oxazolidinone derivatives were screened for antimycobacterial activity against susceptible (Mycobacteriumtuberculosis (Mtb) H37Rv) and resistant (isoniazid (INH)-resistant Mtb (SRI 1369), rifampin (RMP)-resistant Mtb (SRI 1367), and ofloxacin (OFX)-resistant Mtb (SRI 4000)) Mtb strains. Most of the compounds showed moderate to strong antimycobacterial act...

SETTING Treatment of multidrug-resistant tuberculosis (MDR-TB) is often based on drug susceptibility testing (DST) results; for this reason, rapid, simple DST methods are sought which could be applied in resource-poor countries. One such method is a nitrate reductase colorimetric assay known as the Griess method. In Peru, where the incidence rate of TB is among the highest in South America, the...

The Bactec MGIT 960 system is a rapid and reliable automated method for drug susceptibility testing of Mycobacterium tuberculosis complex (MTBC) that yields a high percentage of agreement with the standard method. The microscopic cord morphology of M. tuberculosis in liquid medium is characteristic, and readily differentiates MTBC from nontuberculous mycobacteria (NTM). The goals of this study ...

Therapeutic drug monitoring in tuberculosis remains controversial. We evaluated the relationship between antituberculosis drug levels in blood and clinical outcome. Serum concentrations of first-line antituberculosis drugs were measured in tuberculosis patients between March 2006 and April 2013. Venous blood was drawn 2 h after drug ingestion and was analyzed using high-performance liquid chrom...


 Introduction : Multidrug-resistant TB (MDR TB) is a type of that resistant to at least two the first-line antimicrobials, isoniazid (INH) and rifampin (RMP), with or without resistance other antimicrobials. The factors causing MDR-TB were age, gender, education level, income, occupation, medication adherence, knowledge, attitudes, stigma, smoking habits, role PMO, side effects treatment....

In this paper we present a new dynamic, cache coherence protocol for Software Distributed Shared Memory (SDSM) systems that adopt the scope-consistency model[7]. We initially outline our basic protocol, called Reduced Message Protocol (RMP), and then propose two enhancements: the Multiple Home RMP (RMP-MH) and the Lock Migration RMP (RMP-LM). The experimentation we conducted with the proposed p...

Among circulating cell-derived microparticles, those derived from red cells (RMP) have been least well investigated. To exploit potential haemostatic benefit of RMP, we developed a method of producing them in quantity, and here report on their haemostatic properties. High-pressure extrusion of washed RBC was employed to generate RMP. RMP were identified and enumerated by flow cytometry. Their s...

RMP has been shown to function in the transcription regulation through association with RNA polymerase (RNAP) II subunit RPB5. It also has been shown to be required for the proliferation of hepatocellular carcinoma (HCC) cells with an antiapoptotic property. In this article, we further demonstrate that RMP displays distinct features in HCC cells compared with normal hepatic cells. RMP expressio...

Neisseria gonorrhoeae (N. gonorrhoeae) outer membrane protein reduction modifiable protein (Rmp) has strong immunogenicity. However, anti-Rmp antibodies block rather than preserve the antibacterial effects of protective antibodies, which hampers the development of vaccines for gonococcal infections. We herein constructed an Rmp deletion mutant strain of N. gonorrhoeae by gene homologous recombi...