We have read with great interest the article of Simionescu C et al. (“Uterine pseudotumors”, Rom J Morphol Embryol, 2011, 52(3):743–748) [1]. This authors described “signet-ring stromal tumor” (SRST) and consider this lesion as “an unusual reactive process, which is suggested to be more frequent that it has been thought”. The microscopic illustration of the lesion is not reported. This patholog...

The leukocyte infiltrate of human and murine epithelial cancers is regulated by chemokine production in the tumor microenvironment. In this article, we tested the hypothesis that chemokine receptor antagonists may have anticancer activity by inhibiting this infiltrate. We first characterized CC chemokines, chemokine receptors, and the leukocyte infiltrate in the 410.4 murine model of breast can...

A 70-year-old man with a long history of diabetes mellitus presented to our hospital (Department of Ophthalmology, Sahm Yook Medical Center, Seoul, Korea) complaining of severe ocular pain and visual disturbance in his left eye that had started three days prior to admission. A round 3.7 × 5.0 mm dense central stromal infiltrate with an overlying epithelial defect was noted on slit-lamp examinat...

OBJECTIVE We analyzed the histologic and immunohistochemical changes in the endometrial leukocytic subpopulations to determine which of them are characteristic of chronic endometritis. RESULTS Endometrial biopsies from 25 cases of chronic endometritis and 35 controls were studied. Characteristic morphologic findings included the presence of a plasma cell infiltrate, and a prominent, albeit no...

A 39-year-old woman presented to our hospital with a history of photorefractive keratectomy (PRK), performed two weeks prior; slit-lamp examination revealed diffuse conjunctival congestion, corneal ulcer and stromal infiltration. After 5 days of antifungal and antibacteric treatment, the infiltrate progressively increased so that a therapeutic penetrating keratoplasty was necessary. The microbi...

Background: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign chronic ulcerative lesion of the oral mucosa of an unclear pathogenesis characterized by a mixed infiltrate of inflammatory cells including large mononuclear cells, lymphocytes and eosinophils. This study was designed to find any possible correlation between the number of different cells infiltrates and the...

Tumor infiltrating lymphocytes in primary breast cancer (TIL) are acknowledged measures of disease free survival (DFS) in adjuvant and neoadjuvant settings. Little is known about the biology of metastasis infiltrating lymphocytes (mTIL) although the local immunity of the metastatic site may critically influence the infiltrate composite. To address this question, we compared mTIL with their matc...

purpose: to describe a new noninvasive method to assure correct orientation of donor lenticules in descemet stripping automated endothelial keratoplasty (dsaek) surgery. methods: dsaek surgery was performed in three eyes with the diagnosis of pseudophakic bullous keratopathy (pbk). for the laboratory part of the study, two whole globes and two precut corneoscleral buttons were used. the donor l...

simultaneous a collision tumor of stomach consisting of adenocarcinoma and gastrointestinal stromal tumor (gist) is very rare based on our knowledge. this coexistence has rarely been reported in literatures. we report a case of 64-year-old woman who has diagnosed with prepyloric poorly-differentiated diffuse signet-ring cell type adenocarcinoma and has undergone an elective d2 total gastrectomy...