O conceito de balão eluidor de fármaco (DEB) assenta na libertação na parede vascular de uma droga antiproliferativa sem necessidade de deixar nenhuma estrutura metálica ou sequer um polímero. Trata-se, sem dúvida, de uma ideia aliciante e uma inovação importante na cardiologia de intervenção. A sua introdução no tratamento da doença das coronárias não se fez, contudo, há muitos anos. Porém, o ...

Background Disordered eating behaviours (DEB) are significant public health challenges among adolescents. DEB are prevalent among Chinese young people and replication epidemiological studies in DEB are needed due to ongoing rapid modernization and socio-economic change. In addition, there has been no prevention or intervention programs for DEB in most of rural areas in China and research in DEB...

The effects of parenteral pilocarpine, atropine, and norepinephrine on salt and water transport were studied in jejunum and ileum of anesthetized rats. Pilocarpine increased jejunal transmural PD, reduced absorption of Na, K, HCO3, and H2O, and increased secretion of Cl; in ileum, it caused secretion of Na and H2O, elicited secretion of K, and reduced the absorption of Cl. In both segments, per...

variations in phosphatidate phosphohydrolase (pap) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. pap activity in adipose tissue was elevated by 61% during pregnancy. the increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). estradiol injecting into non-pregnant rats increased ...

background: acute kidney injury (aki) is a common and life-threatening complication following coronary artery bypass graft (cabg). neutrophil gelatinase-associated lipocalin (ngal) and cystatin c have shown to be good predictive factors for aki. recently, there has been a growing interest in the use of hypertonic saline in cardiac operations. the purpose of this study was to evaluate the prophy...

The egg peptide speract increases intracellular pH (pHi) and cyclic nucleotides in sperm of the sea urchin Strongylocentrotus purpuratus by a mechanism dependent on seawater Na+ but not Ca2+ (Hansbrough, J. R., and Garbers, D. L. (1981) J. Biol. Chem. 256, 2235-2241; Repaske, D. R., and Garbers, D. L. (1983) J. Biol. Chern. 258, 6025-6029). Using the Ca2+ indicators quin2 and indo1, we show tha...

Fanconi anemia (FA) is characterized clinically by a progressive pancytopenia, diverse congenital abnormalities and increased predisposition to malignancy. Although a variable phenotype makes accurate diagnosis on the basis of clinical manifestations difficult in some patients, study of cellular sensitivity to the clastogenic effect of DNA cross-linking agents such as diepoxybutane (DEB) has be...

A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMC) is an important stimulus for cell contraction, migration, and proliferation. Depletion of intracellular Ca2+ stores opens store-operated Ca2+ channels (SOC) and causes Ca2+ entry. Transient receptor potential (TRP) cation channels that are permeable to Na+ and Ca2+ are believed to form functional ...

Exercise-associated hyponatremia (EAH) is a well know electrolyte disorder in endurance athletes. Although fluid overload is the most like etiology, recent studies, however, argued whether EAH is a disorder of vasopressin secretion. The aims of the present study were to investigate (i) the prevalence of EAH in male ultra-marathoners and (ii) whether fluid intake, aldosterone or vasopressin, as ...