ABSTRACT Receiver operating characteristics (ROC) curve with the calculation of area under curve (AUC) is a useful tool to evaluate the performance of biomedical and chemoinformatics data. For example, in virtual drug screening ROC curves are very often used to visualize the efficiency of the used application to separate active ligands from inactive molecules. Unfortunately, most of the availab...

Rocker (gene symbol rkr), a new neurological mutant phenotype, was found in descendents of a chemically mutagenized male mouse. Mutant mice display an ataxic, unstable gait accompanied by an intention tremor, typical of cerebellar dysfunction. These mice are fertile and appear to have a normal life span. Segregation analysis reveals rocker to be an autosomal recessive trait. The overall cytoarc...

BACKGROUND Osteoarthritis of the first metatarsophalangeal joint (1st MTPJ OA) is a common and disabling condition commonly managed with footwear and orthotic interventions. The objective of this study was to identify factors associated with a successful treatment response in people with 1st MTPJ OA provided with prefabricated orthoses or rocker-sole footwear as part of a randomised clinical tr...

Bilateral amputees who are fitted with standard full length prostheses find it difficult to walk fast or climb up and down stairs. Usually stubbies, or short prostheses with non-articulated rocker bottoms, are also provided, especially for geriatric amputees. An interchangeable system has been evolved which enables the same prosthesis to be used either as a full length prosthesis or as a stubby...

The purpose of this study was to examine the external work performed by individuals wearing a rocker bottom shoe compared to a standard shoe. It was hypothesized that individuals wearing a rocker bottom shoe would have changes in the amount of work over the course of contact with the ground. External work on the body’s centre of mass (BCOM) was calculated for individuals in both conditions. Com...

......................................................................................................1 0 Chapter 1: Introduction ................................................................................................................. 12 1.1 Diabetes and the impact of plantar foot ulcers ................................................................. 12 1.2 Aetiology of ulceration in...

PURPOSE Nowadays, fashion has caused that many young women are wearing high-heeled shoes. Therefore, the aim of this study was to examine the effects of long-term walking in high-heeled shoes on the foot mechanics during barefoot gait. METHODS Forty-three young women (22 ± 2.1 years) divided into two groups participated in this retrospective cohort study. The first group was composed of women...