نتایج جستجو برای: rora
تعداد نتایج: 204 فیلتر نتایج به سال:
اوتیسم، اختلالی نوروژنتیکی است که تا قبل از سه سالگی و با اختلالات عدیده در برقراری ارتباطات اجتماعی و تکلم در کودکان بروز می یابد. با این حال، اخیراً آن را نوعی اختلال چند-ژنی با تأثیرات عمیق اپی ژنتیک بر پاتولوژی آن معرفی کرده اند. بر اساس گزارشات اخیرِ،، خاموشی اپی ژنتیکی ژن rora (که نقشی کلیدی در تکامل بافت عصبی دارد)، بر اثر متیلاسیون نواحی پروموتری آن در کودکان اوتیسمی رخ می دهد که قادر است...
Spinocerebellar ataxia type 1 (SCA1) is one of nine dominantly inherited neurodegenerative diseases caused by polyglutamine tract expansion. In SCA1, the expanded polyglutamine tract is in the ataxin-1 (ATXN1) protein. ATXN1 is part of an in vivo complex with retinoid acid receptor-related orphan receptor alpha (Rora) and the acetyltransferase tat-interactive protein 60 kDa (Tip60). ATXN1 and T...
Retinoic acid receptor-related orphan receptor alpha (RORA) plays a key role in the regulation of lipid and glucose metabolism and insulin expression that are implicated in the development of type 2 diabetes mellitus (T2DM). However, the effects of genetic variants in the RORA gene on the susceptibility to T2DM remain unknown. Nine tagging single-nucleotide polymorphisms (SNPs) were screened by...
Retinoic acid receptor-related Orphan Receptor alpha (RORalpha) is a member of the nuclear hormone receptor superfamily. RORalpha has long been considered as a constitutive activator of transcription in the absence of exogenous ligand; however, cholesterol has recently been identified as a natural ligand of RORalpha. The spontaneous staggerer (sg/sg) mutation is a deletion in the Rora gene that...
This study used selected lambs that varied in their resistance to the gastrointestinal parasite Teladorsagia circumcincta. Infection over 12 weeks identified susceptible (high adult worm count, AWC; high fecal egg count, FEC; low body weight, BW; low IgA) and resistant sheep (no/low AWC and FEC, high BW and high IgA). Resistance is mediated largely by a Th2 response and IgA and IgE antibodies, ...
OBJECTIVES The thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic analyses to localize individual genes acting pleiotropically upon these phenot...
BACKGROUND Interleukin (IL)-17 produced by mainly T helper 17 (Th17) cells may play an important destructive role in chronic periodontitis (CP). Thus, anti-inflammatory cytokines, such as IL-35, might have a beneficial effect in periodontitis by inhibiting differentiation of Th17 cells. Th17 differentiation is regulated by the retinoic acid receptor-related orphan receptor (ROR) α (encoded by R...
در سال های اخیر امنیت آب بطور گسترده مطرح شده و منجر به رشد عمومی و تصمیم گیری در مورد آن گردیده است.آب موجود در حوزه آبخیز اساسا رواناب و جریان رودخانه را در بر می گیرد. در این شرایط رودخانه های فصلی موجود تنها به بارش و گاهی اوقات به رفتارتغذیه ای آب زیر زمینی وابسته اند. در این مطالعه محاسبه آب پایه و تغذیه آب زیر زمینی با استفاده از هیدروگراف رودخانه و مدل تحلیلی داده های روزانه جریان رودخا...
The ATP-dependent nuclease, exonuclease V, of Escherichia coli plays an important role in repair and recombination. The enzyme is composed of two subunits, one of which is the product of the recB and recC genes. In this communication it is shown by mapping and complementation experiments that the rorA mutation, which results in radiation sensitivity but not the loss of recombination ability, is...
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