background: alopecia areata (aa) is a noncicatricial (nonscarring) alopecia. the association between aa and celiac disease (cd) is debatable. several studies declare the relationship between aa and cd as measurement of celiac autoantibodies (anti‑gliadin iga and anti‑gliadin igg), but a few studies consider anti‑tissue transglutaminase iga. the aim of this study was to evaluate the frequency di...

objective: evidence shows periodontally infected patients may be at a higher risk of thrombotic accidents and adverse pregnancy outcomes, via induced systemic inflammatory mediators' production. some authors have concluded that increase in systemic inflammatory markers occurs together with increase in serum levels of auto antibodies including anti-cardiolipin antibody (acla). the aim of the pre...

for the evaluation of autoantibodies in pemphigus vulgaris (pv), an indirect elisa assay was developed by using a semi-purified human epidermal skin extracted with approximately a molecular weight (m.w.) of 130-160 kda. the evaluation of pemphigus igg, igm and iga autoantibodies in 75 patients and 50 control sera indicated that this indirect elisa assay was a useful method for the detection of ...

Hyperplasia by Maternal Plasma Analysis: A Feasibility Study, Rossa W.K. Chiu, Tze K. Lau, Pik T. Cheung, Zhi Q. Gong, Tse N. Leung, and Y.M. Dennis Lo (Departments of 1 Chemical Pathology and 2 Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR; 3 Department of Paediatrics, The University of Hong Kong, Hong Kong SAR; * address correspondence to this author at: Depar...

systemic sclerosis is a generalized disorder of connective tissue clinically characterized by thickening and fibrosis of the skin and by distinctive forms of involvement of internal organs. one of the hallmarks of systemic sclerosis is the presence of serum autoantibodies against a variety of nuclear and cytoplasmic antigens. the primary purpose of this study was to identify the autoantibodies ...

multiple sclerosis (ms) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by cd4+ t cells with a proinflammatory t helper (th)1 and th17 phenotypes, macrophages, and soluble inflammatory mediators. the overactive  pro-inflammatory  th1  cells  and  clonal  expansion  of  b  cells  initiate  an inflammatory cascade with several cellular and ...

Three murine monoclonal anti-ssDNA autoantibodies have been produced by fusion of spleen cells from NZB/NZW F1 hybrid mice with Sp2/0-Ag 14 murine myeloma cells. Specificity studies characterizing monoclonal anti - ssDNA autoantibodies revealed binding patterns for nucleotides. Clone E-4-1 showed preferential binding with mono-di-and polyguanosine. Clones E-4-4 and E-11-1 specitically bound mon...

beta 2 glycoprotein i (β2gpi) is a single chain 50 kda highly glycosylated glycoprotein at an approximate concentration of 4 μm in cells. the abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. in addition, β2gpi has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...