background human rotavirus is a significant cause of severe gastroenteritis in infants and young children worldwide. in recent years, rotavirus genotyping by rt-pcr has provided valuable information about the diversity of rotaviruses circulating worldwide. the purpose of the present study is to monitor the prevalence of the different g types of rotaviruses circulating in shiraz, southern iran a...

Rotaviruses infect mature, differentiated enterocytes of the small intestine and, by an unknown mechanism, escape the gastrointestinal tract and cause viremia. The neonatal rat model of rotavirus infection was used to determine the kinetics of viremia, spread, and pathology of rotavirus in extraintestinal organs. Five-day-old rat pups were inoculated intragastrically with an animal (RRV) or hum...

background: rotavirus is one of the most common etiologic agent of severe acute diarrhea in infants and children which results in high mortality and morbidity globally. prophylactic strategies are required to prevent acute rotavirus diarrhea. recently, the beneficial effect of probiotic therapy in control of rotavirus diarrhea was noted in many investigations. this systematic review investigate...

Background. The cumulative annual statistics of rotavirus-associated gastroenteritis are about 25 million outpatient visits, 2 hospitalizations, and 180,000–450,000 deaths in children under 5 years age.
 Aim: To analyze the manifestations complications rotavirus compared with non-rotavirus UK children.
 Materials methods. A retrospective hospital-based case-control study was conducted...

A 1:1 matched case-control study of calves under 1 month of age was carried out by weekly visits to 7 dairy farms in Mashhad from May 2008 to October 2008. Fecal samples were collected from a total of 112 calves with clinical signs of diarrhea and from 112 matched animals without clinical signs of diarrhea as assessed by a scoring system. The samples were investigated for the presence of Rotavi...

Background: Rotavirus is a major cause of acute diarrhea in children worldwide. It is an important cause of death among young children in developing countries. The aim of this study was to evaluate the prevalence of rotavirus infection in children less than five years old hospitalized for gastroenteritis in Jahrom. Methods: One hundred and two stool samples were collected from children less tha...

BACKGROUND Approximately 39% of the global diarrhoea deaths in children aged 5 years may be attributable to rotavirus infection. Two rotavirus vaccines were recently introduced to the market, with evidence of efficacy in the USA, Europe and Latin America. We sought to estimate the effectiveness of these vaccines against rotavirus morbidity and mortality. METHODS We conducted a systematic revi...

INTRODUCTION Rotavirus remains the leading cause of severe diarrhea in children under 5 years worldwide. In the US, Rotarix (RV1) and RotaTeq (RV5), have been associated with reductions in and severity of rotavirus disease. Studies have evaluated the impact of RV1 or RV5 but little is known about the impact of incomplete or mixed vaccination upon vaccine effectiveness. METHODS Case control st...

BACKGROUND Rotavirus vaccine is recommended for routine use in all countries globally. To facilitate decision making on rotavirus vaccine adoption by countries, help donors prioritize investments in health interventions, and monitor vaccine impact, we estimated rotavirus mortality for children <5 years of age from 2000 to 2013. METHODS We searched PubMed using the keyword "rotavirus" to ident...

background: vp4 protein is as spikes on rotavirus outer capsid shell which is responsible for virus attachment to the host. vp4 induces production of neutralizing antibodies which could be used for serotyping of different isolates. methods: simian rotavirus sa11 gene 4 cdna was cloned into a cloning plasmid pdonrtm by recombination reaction using clonase ii enzyme mix. the resulting clone was c...