نتایج جستجو برای: rs10757278
تعداد نتایج: 37 فیلتر نتایج به سال:
BACKGROUND Recent genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) and myocardial infarction (MI). The 9p21.3 locus was verified by numerous replication studies to be the first common locus for CAD and MI. In the present study, we investigated whether six single nucleotide polymorphisms (SNP) rs1333049, rs1333040, rs10757274, rs2383206...
BACKGROUND Recent studies on genome-wide association have identified common variants on chromosome 9p21 associated with coronary artery disease (CAD). Given that ischemic stroke and CAD share several aspects of etiology and pathogenesis, we investigated the association of variants on chromosome 9p21 with ischemic stroke and CAD in the Chinese Han population by capturing the majority of diversit...
Dear Editor, The recent paper by Kundi et al. provided evidence of the increased risk developing severe Covid-19 disease in patients that are older and frail [1.Kundi H. Çetin E.H.Ö. Canpolat U. Aras S. Celik O. Ata N. al.The role frailty on adverse outcomes among with covid-19.J Infect. 2020; 81: 944-951Abstract Full Text PDF PubMed Scopus (44) Google Scholar]. However, underlying mechanisms d...
BACKGROUND Common variation at chromosome 9p21 (marked by rs10757278 or rs1333049) is associated with coronary artery disease (CAD) and peripheral vascular disease. A decreasing effect at older age was suggested, and effects on long-term mortality are unclear. We estimated 9p21 associations with CAD and all-cause mortality in a CAD diagnosis-free older population. We also estimated classificati...
BACKGROUND AND PURPOSE The purpose of this study was to replicate the previous association of single nucleotide polymorphisms (SNPs) with risk of intracranial aneurysm (IA) and to examine the relationship of smoking with these variants and the risk of IA. METHODS White probands with an IA from families with multiple affected members were identified by 26 clinical centers located throughout No...
2008 has brought us the first fruits from genomewide association studies (GWASs), an unbiased and comprehensive approach to identify common risk alleles for complex diseases of adulthood. By genotyping 310 000 single nucleotide polymorphisms (SNPs) in over 1700 intracranial aneurysm (IA) cases and 7400 controls from Finland and the Netherlands, a multinational team of investigators recently ide...
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