نتایج جستجو برای: rupture force

تعداد نتایج: 228886  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Jingyuan Li Julio M Fernandez B J Berne

In atomic force spectroscopic studies of the elastomeric protein ubiquitin, the β-strands 1-5 serve as the force clamp. Simulations show how the rupture force in the force-induced unfolding depends on the kinetics of water molecule insertion into positions where they can eventually form hydrogen bonding bridges with the backbone hydrogen bonds in the force-clamp region. The intrusion of water i...

Journal: :Biophysical journal 2012
Sebastian Getfert Peter Reimann

In dynamic force spectroscopy, a (bio-)molecular complex is subjected to a steadily increasing force until the chemical bond breaks. Repeating the same experiment many times results in a broad distribution of rupture forces, whose quantitative interpretation represents a formidable theoretical challenge. In this study we address the situation that more than a single molecular bond is involved i...

2011
Simon Martin Fugmann Christoph Markschies Andreas Herrmann Igor M. Sokolov Michael Urbakh

This work intends to show how the coupled dynamics of a nonlinear polymer chain alters processes such as thermal fragmentation and force-induced rupture. For that purpose we first examine the equilibrium relaxation properties of nonlinear polymer chains which have a distinct impact on all dynamical processes in such systems. We find that in chains with nonlinear interaction potentials the relax...

Journal: :ماشین های کشاورزی 0
کبری هدایتی باقر عمادی مهدی خجسته پور شهرام بیرقی طوسی

sugar, which can be extracted from sugar cane and sugar beet, is one of the most important ingredients of food. conducting more research to increase the extraction efficiency of sugar is necessary due to high production of sugar beet and its numerous processing units in northern khorasan province. in this research, the effect of temperature, time and the frequency of ultrasonic waves on mechani...

Journal: :Small 2017
Josep Relat-Goberna Amy E M Beedle Sergi Garcia-Manyes

The nanomechanics of lipid membranes regulates a large number of cellular functions. However, the molecular mechanisms underlying the plastic rupture of individual bilayers remain elusive. This study uses force clamp spectroscopy to capture the force-dependent dynamics of membrane failure on a model diphytanoylphosphatidylcholine multilayer stack, which is devoid of surface effects. The obtaine...

2012
Yong J Yuan Renjie Jia

Bond-rupture scanning for biomedical diagnostics is examined using quartz crystal microbalance (QCM) experiments and microparticle mechanics modeling calculations. Specific and nonspecific interactions between a microparticle and its binding QCM surface can be distinguished by gradually increasing the amplitude of driving voltage applied to QCM and monitoring its frequency changes. This researc...

2007
T. Erdmann S. Pierrat P. Nassoy U. S. Schwarz

We probe the dynamic strength of multiple biotin-streptavidin adhesion bonds under linear loading using the biomembrane force probe setup for dynamic force spectroscopy. Measured rupture force histograms are compared to results from a master equation model for the stochastic dynamics of bond rupture under load. This allows us to extract the distribution of the number of initially closed bonds. ...

Journal: :Biophysical journal 2013
Sigurður Ægir Jónsson Simon Mitternacht Anders Irbäck

Single-molecule pulling experiments on unstructured proteins linked to neurodegenerative diseases have measured rupture forces comparable to those for stable folded proteins. To investigate the structural mechanisms of this unexpected force resistance, we perform pulling simulations of the amyloid β-peptide (Aβ) and α-synuclein (αS), starting from simulated conformational ensembles for the free...

Journal: :Biophysical journal 2013
Kristian Boye Agnieszka Ligezowska Johannes A Eble Bernd Hoffmann Beate Klösgen Rudolf Merkel

Dynamic force spectroscopy was used to test force-induced dissociation of the complex between the integrin α7β1 and the bacterial protein invasin. Both proteins were used in truncated forms comprising the respective binding sites. Using the biomembrane force-probe, the bond system was exposed to 14 different loading rates ranging from 18 pN/s to 5.3 nN/s. At each rate, bond rupture spectra were...

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