The relationship between the enzymatic and the transcriptional activity of the bifunctional protein pterin-4a-carbinolamine dehydratase/dimerization cofactor for hepatocyte nuclear factor 1 (DCoH) has been elucidated by site-directed mutagenesis. DCoH dimers harbor a binding site for hepatocyte nuclear factor 1 (HNF1), two active centers that bind pterins, and a saddle-shaped surface that resem...

Background A full understanding of the geometry of the nonplanar saddle-shaped mitral annulus can provide valuable information regarding the pathophysiology of mitral regurgitation (MR). Aim of the work To investigate mitral annular geometric deformities using three-dimensional echocardiography among patients with ischemic coronary illness with and without mitral regurgitation. Methods Thre...

We investigated the perception of local surface orientation on a simple smooth object, under several different illumination conditions. The perceived local orientation was determined for several points on the surface and quantified as slant and tilt of the local tangent plane. We found an underestimation of the perceived slant and a larger variance for the perceived tilt than for the perceived ...

We establish existence and qualitative properties of saddle-shaped solutions of the elliptic fractional equation (−∆)u = f(u) in all the space R, where f is of bistable type. These solutions are odd with respect to the Simons cone and even with respect to each coordinate. More precisely, we prove the existence of a saddle-shaped solution in every even dimension 2m, as well as its monotonicity p...

We present a combined low-temperature scanning tunneling microscopy and near-edge X-ray adsorption fine structure study on the interaction of tetrapyridyl-porphyrin (TPyP) molecules with a Cu(111) surface. A novel approach using data from complementary experimental techniques and charge density calculations allows us to determine the adsorption geometry of TPyP on Cu(111). The molecules are cen...

Tetraphenylenes 2 with eight peripheral gallic esters were prepared in two steps from octamethoxytetraphenylene 1 in 19-72% yield. Investigation of the mesomorphic properties of 2 by DSC, POM and X-ray diffraction revealed that derivatives 2a-d with short alkoxy chain lengths (C(5)-C(8)) did not show any mesomorphic properties, whereas compounds 2e-i with C(9)-C(13) chains displayed rectangular...

The copper phosphinimide complexes [Cu{μ-N[double bond, length as m-dash]PR3}]4 (1, R = NMe2 and 2, R = Ph) were obtained in good yields from the reactions of Cu[Mes] (Mes = mesityl, C6H2Me3-2,4,6) with the corresponding iminophosphoranes, HNPR3. The molecular structures of 1 and 2 reveal the presence of planar eight-membered {Cu4N4} rings which contrasts with the saddle-shaped {M4N4} rings fou...