Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. This report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning. Case report: A 5-year-old girl was presented with acute blindness following closantel poisoning. She was given mistakenly a dose of 500 mg/day (25mg/kg/day) fo...

INTRODUCTION The halogenated salicylanilides are a group of compounds developed mainly for their antiparasitic activity in animals. Closantel and rafoxanide, which represent the most important drugs in this group, are used extensively for the control of Haemonchus spp. and Fasciola spp. infestations in sheep and cattle and Oestrus ovis in sheep in many parts of the world. Clinical signs of clos...

Spin trapping is a very useful technique to study the photochemistry of chemical photosensitizers that undergo electron or hydrogen-transfer (Type I) reactions upon UV or visible irradiation. The Type I photochemistry of chlorpromazine [2-chloro-N-(3-dimethylaminopropy1)-phenothiazine], 3,3'4'5-tetrachlorosalicylanilide and 3,4',5tribromosalicylanilide has been investigated using 2-methyl-2-nit...