The Quality-Adjusted Time Without Symptoms or Toxicity (Q-TWiST) statistic previously introduced by Glasziou, Simes and Gelber (1990, Statistics in Medicine 9, 1259-1276) combines toxicity, disease-free survival, and overall survival information in assessing the impact of treatments on the lives of patients. This methodology has received positive reviews from clinicians as intuitive and useful,...

Nowadays high trend of human machinery life, high utilizing vehicles, avoiding urban public place along with neglecting identity, cultural and social values of these places make that the places in urban different scales dismiss their importance and real role. In recent decades, designing public places in urban different scales has been considered as awesome effort to meet human social needs. Th...

Laws of large numbers imply for a sequence of i.i.d. random variables X1, X2, . . . with mean μ, the sample average, 1 n (X1 + X2 + · · · + Xn), converges to μ as n goes to infinity. Concentration bounds provide a quantitative distance between the sample average and the expectation. In this lecture we review several of these fundamental inequalities. In the next few lectures we will see applica...

We consider the reliable multi configuration capacitated logistics network design problem (RMCLNDP) with system disruptions, concerned with facilities locating, transportation links constructing, and also allocating their limited capacities to the customers in order to satisfy their demands with a minimum expected total cost (including locating costs, link constructing costs, as well as expecte...

A General Retrospective Olaf Zimmermann: How did your book come to be? How did you get together, and how did you nd your contributors and reviewers? Bobby Woolf: Martin Fowler was the matchmaker. When he wrote Patterns of Enterprise Application Architecture,2 Kyle Brown pointed out that his pattern language was not addressing asynchronous messaging. Martin felt that he already had plenty of pat...