We present the first documented case of metastatic melanoma to orbit with dedifferentiation. A patient a history lip and other poorly differentiated carcinomas presented both sub-brow an intraorbital mass. Radiographically intraoperatively, mass communicated via perineural spread along supraorbital nerve. Histopathology confirmed diagnosis based on melanocytic markers, SOX-10 Melan-A; dediffere...

ing a mixture of carcinomatous and sarcomatous elements (1). Liver carcinosarcomas are classified as two types including sarcomatoid hepatocellular carcinoma (HCC) and cholangiocarcinoma. A sarcomatoid HCC is a carcinoma that most resembles a sarcoma found in the liver. Only a few cases of intrahepatic sarcomatoid cholangiocarcinomas have been reported (1-6). To the best of our knowledge, an in...

BACKGROUND Sarcomatoid carcinoma is a rare, aggressive, malignant cancer composed of sarcoma and sarcoma-like components, and can occur in different organs such as the thyroid gland, bone, skin, breast, pancreas, liver, urinary tract, and lung. Pulmonary sarcomatoid carcinoma accounts for only a small percentage of lung cancers and has histological variants that include pleomorphic carcinoma, g...

Dedifferentiated liposarcoma (DDL) with divergent dedifferentiation is uncommonly reported variable incidences. Liposarcomas, particularly those manifesting dedifferentiation, occur in the retroperitoneum. They grow into large size, present at very late stages, and can have a poor clinical outcome. Here we rare case of recurrent dedifferentiated dual heterologous differentiation osteosarcoma Ch...

Sarcomatoid component can occur in all histological subtypes of renal cell carcinoma but most commonly accompanies chromophobe renal cell carcinoma. The majority of the sarcomatoid components consist of malignant fibrous histiocytoma, fibrosarcoma or undifferentiated sarcoma areas. Heterologous differentiation in the form of osteosarcoma or rhabdomyosarcoma is very rarely encountered. We report...

Tracheal sarcomatoid carcinoma is an extremely infrequent neoplasm with unclear pathogenesis and clinical outcomes. To date, only two cases have been described in English literature. We report a case of a 37-year-old patient complaining of hemoptysis, dyspnea, and cough. An intraluminal polypoid mass in the trachea was found and ultimately diagnosed as tracheal sarcomatoid carcinoma in the cerv...

Carcinomas with osteoclast-like giant cells (OGCs) are a rare type of malignant tumor that is histologically characterized by the presence of multinucleated giant cells that resemble osteoclasts mixed with poorly differentiated adenocarcinoma cells. In this study, we report the clinicopathological and immunohistochemical features of a gastric sarcomatoid carcinoma with OGCs in a 37-year-old mal...