PURPOSE Standard chemoradiation therapy for stage III non-small cell lung cancer (NSCLCa) results in suboptimal outcomes with a high rate of local failure and poor overall survival. We hypothesize that dose escalation using stereotactic body radiotherapy (SBRT) boost could improve upon these results. We present here a study evaluating the dosimetric feasibility of such an approach. METHODS An...

Stereotactic body radiation therapy (SBRT) has emerged as a new technology in radiotherapy delivery, allowing for potentially curative treatment in many patients previously felt not to be candidates for radical surgical resection of stage I non-small-cell lung cancer (NSCLC). Several studies have demonstrated very high local control rates using SBRT, and more recent data have suggested overall ...

BACKGROUND Intracranial delivery of high-dose radiation treatment with stereotactic techniques has paved the way for treatment of extracranial sites. METHODS The authors review the evolution of stereotactic body radiation therapy (SBRT) and its application to tumors in the lung and abdomen, addressing both the technical concerns associated with treatment delivery and the emerging clinical dat...

This paper proposes two modeling approaches to predict lung tumor dynamics as an effect of radiotherapy. Real clinical information non-small cell cancer (NSCLC) patients undergoing stereotactic body radiation therapy (SBRT) the primary treatment method has been used for numerical simulations. The classical Gompertz model volume growth prediction was modified using a fractional parameter and com...

INTRODUCTION This study aimed to evaluate parenchymal and functional lung changes following stereotactic body radiotherapy (SBRT) for early-stage non-small cell lung cancer (NSCLC) patients and to correlate radiological and functional findings with patient and treatment characteristics as well as survival. MATERIALS AND METHODS Seventy patients with early-stage NSCLC treated with SBRT from 20...

The purpose of this study is to investigate changes in lung tumor internal target volume during stereotactic body radiotherapy treatment (SBRT) using magnetic resonance imaging (MRI). Ten lung cancer patients (13 tumors) undergoing SBRT (48 Gy over four consecutive days) were evaluated. Each patient underwent three lung MRI evaluations: before SBRT (MRI-1), after fraction 3 of SBRT (MRI-3), and...

Stereotactic body radiation therapy (SBRT) has quickly become a preferred treatment option for early-stage lung cancer patients who are ineligible for surgery. This technique uses tightly conformed megavoltage (MV) x-ray beams to irradiate a tumour with ablative doses in only a few treatment fractions. Small high energy x-ray fields can cause lateral electron disequilibrium (LED) to occur withi...

PURPOSE To develop an automated technique for evaluating lung stereotactic body radiotherapy (SBRT) plan quality and predicting achievable lung dose constraints. METHODS We examined the workflow scripting capabilities of a radiation oncology software package (MIM Software Inc) for automatically generating mean dose gradients and overlap volume histograms (OVHs) for lung SBRT plans. Mean dose ...

The purpose of the study was to evaluate the time effectiveness and dose distribution details of dynamic jaw delivery compared to the regular helical tomotherapy delivery mode in stereotactic body radiation therapy (SBRT) of liver and lung tumors. Ten patients with liver and ten patients with lung tumors were chosen to analyze the dose profiles and treatment times of regular helical tomotherapy...

Although the method utilizing the maximum standard uptake value (SUVmax) 18F-FDG Positron Emission Tomography (PET) to assess the outcome of lung stereotactic body radiotherapy (SBRT) has been widely accepted in practice, its reliability has frequently been challenged i . The purpose of this study is to explore and test a novel method using a self background-corrected SUVmax (cSUVmax) in detect...