schizophrenia is a severe neuropsychiatric disorder with symptoms such as hallucination, delusion and mental disorder. it is a complex disorder, in which genetic components play a crucial role in its pathogenesis. among candidate genes for schizophrenia, neuregulin 1 (nrg1) gene is the most important gene,  association of which with the illness has been confirmed in several studies. single nucl...

objective: suicide is one of the most important early causes of death in psychotic patients. the main object of this research was to determine the relationship between positive and negative symptoms of schizophrenia and psychotic major depressive disorder (mdd) with suicidal history and risk. methods: sixty five patients with schizophrenia compared to 65 patients with psychotic mdd in a cross s...

OBJECTIVE This overview focuses on neurobiological abnormalities found in subjects with schizotypal personality disorder, the prototype of the schizophrenia spectrum disorders, and chronic schizophrenia in the context of common vulnerabilities shared by schizotypal personality disorder and schizophrenia, as well as the factors that protect against the severe cognitive/social deficits and frank ...

social anxiety is a frequent, disabling condition but often unrecognized feature in schizophrenia. the aim of this study was to describe the prevalence of social anxiety among inpatients with schizophrenia. sixty inpatients with dsm-v schizophrenia were recruited from niayesh psychiatric hospital in 2015 in tehran, iran. they were interviewed with the anxiety disorders section of the scid for d...

objective: schizophrenia is a complex widespread neuropsychiatric disorder. this illness encompasses a complex debilitating mental disorder causing illusion, delusion, disturbed relationship, low motivation and decline of emotion. viral infection of the brain including borna disease virus (bdv) may play a role in transient or permanent neurological and behavioral abnormalities. this role of bor...

BACKGROUND Cognitive impairments are well-established features of schizophrenia, but there is ongoing debate about the nature and degree of cognitive impairment in patients with schizoaffective disorder and bipolar disorder. We hypothesized that there is a spectrum of increasing impairment from bipolar disorder to schizoaffective disorder bipolar type, to schizoaffective disorder depressive typ...

BACKGROUND Serious mental illnesses are associated with increased risk of cardiometabolic comorbidities. The objective of this study was to evaluate the prevalence of cardiometabolic comorbidity and its association with hospitalization outcomes and costs among inpatients with schizophrenia or bipolar disorder. METHODS This retrospective database analysis reviewed patients with an inpatient di...

Social anxiety is a frequent, disabling condition but often unrecognized feature in schizophrenia. The aim of this study was to describe the prevalence of social anxiety among inpatients with schizophrenia. Sixty inpatients with DSM-V schizophrenia were recruited from Niayesh psychiatric hospital in 2015 in Tehran, Iran. They were interviewed with the Anxiety Disorders section of the SCID for D...

Introduction: Schizophrenia is a chronic heterogenic neurodevelopment disorder. Many genes interfere in the development of SCZ. All four genes, NrCAM, PRODH, ANK3, and ANKK1, which were evaluated in this study, were previously reported to be associated with Schizophrenia. The NrCAM contributes to creating cognitive deficiencies through the CAM’s signaling pathway. PRODH plays a vital role in cr...

Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had s...