Tolerance to central hypovolemia is highly variable, and accumulating evidence suggests that protection of anterior cerebral blood flow (CBF) is not an underlying mechanism. We hypothesized that individuals with high tolerance to central hypovolemia would exhibit protection of cerebral oxygenation (ScO2), and prolonged preservation of CBF in the posterior vs. anterior cerebral circulation. Eigh...

Mutations in SCO2, a metallochaperone involved in mitochondrial copper delivery, are associated with early onset, fatal hypertrophic cardiomyopathy. All reported patients carry at least one copy of the common 1541G>A (E140K) mutation. Whereas patients with one copy of the E140K allele, in combination with a more deleterious mutation, follow a severe clinical course, patients homozygous for the ...

The oil in mackerel viscera was extracted by supercritical carbon dioxide (SCO2) at a semi-batch flow extraction process and the fatty acids composition in the oil was identified. Also the off-flavors removal in mackerel viscera and the storage improvement of the oils were carried out. As results obtained, by increasing pressure and temperature, quantity was increased. The maximum yield of oils...

Increased mitochondrial biogenesis by activation of PPAR- or AMPK/PGC-1α-dependent homeostatic pathways has been proposed as a treatment for mitochondrial disease. We tested this hypothesis on three recombinant mouse models characterized by defective cytochrome c-oxidase (COX) activity: a knockout (KO) mouse for Surf1, a knockout/knockin mouse for Sco2, and a muscle-restricted KO mouse for Cox1...

THE CRITICAL IMPORTANCE of cerebral blood flow (CBF) control was reported in 1890 in a landmark publication by Roy and Sherrington (15). Although the concept was not fully accepted until confirmed by more sophisticated methods of CBF assessment, these authors postulated that local changes in cerebral functional activity and perfusion are coupled. In this issue of the Journal of Applied Physiolo...

p53 is well known as the "guardian of the genome" for differentiated and neoplastic cells. p53 induces cell-cycle arrest and cell death after DNA damage and thus contributes to the maintenance of genomic stability. In addition to this tumor suppressor function for pro-oncogenic cells, p53 also plays an important role as the central regulator of stress response by maintaining cellular homeostasi...

Supercritical and trans-critical carbon dioxide cycles are widely used for refrigerators, heat pumps power plants, of which the exchangers key components. This article presents a critical review cooled supercritical (SCO2) flows, within CO 2 is close to its point thus likely experience transfer deterioration or enhancement due dramatical change thermo-physical properties. First, SCO2 features w...

The glucose metabolism reprogramming is a hallmark of cancer. The oncoprotein hepatitis B X-interacting protein (HBXIP) functions in the development of breast cancer. In this study, we supposed that HBXIP might be involved in the glucose metabolism reprogramming in breast cancer. We showed that HBXIP led to increases in generation of intracellular glucose and lactate, as well as decreases in ge...

Foil bearings are an integral part of oil-free turbomachines which have been selected as a potential technology to enable cost efficient Supercritical Carbon Dioxide Brayton cycle for solar power application. Using high pressure CO2 as the operating fluid means that within the film Reynolds numbers in the highly turbulent regime are observed, therefore, using traditional simulation tools, such ...