Background Among the chemical class of coumarins several substances have been described to be effective as cognition enhancers. We have recently characterized the coumarin scopoletin as a compound which fits a pharmacophore model of AChE inhibitors and enhances the release of ACh in rat brain [1]. Now, a comprehensive study was carried out in order to investigate the effects of scopoletin on le...

The phytochemical investigation of an ethanol extract of Artemisia afra led to the isolation of six known compounds, acacetin (1), 12α,4α-dihydroxybishopsolicepolide (2), scopoletin (3), α-amyrin (4), phytol (5), and a pentacyclic triterpenoid betulinic acid (6). The compounds were evaluated for antimicrobial activity against Gram positive (Actinomyces naeslundii, Actinomyces israelii, and Str...

The sorption of the allelochemical scopoletin (7-hydroxy-6-methoxycoumarin) was studied in eight agricultural soils and different model sorbents. We also determined its degradation selected related results to expression phytotoxicity soil towards two plant species, Eruca vesicaria Hordeum vulgaris. Scopoletin sorbed a greater extent acid than alkaline soils. Correlations with properties indicat...

Abstract Scopoletin is a phytochemical of coumarins distributed in some plants. The aim this study was the evaluation scopoletin content and antioxidant activity nettle, mallow, purslane, knot-grass, dill coriander encountered Black Sea regions. Analyses were conducted on leaves stems these plants, except knot-grass. lowest found nettle (11.48 mg/kg) highest amount knot-grass (6708.37 mg/kg). n...

The host immune system is the first line of host defense, consisting mainly of innate and adaptive immunity. Immunity must be maintained, orchestrated, and harmonized, since overactivation of immune responses can lead to inflammation and autoimmune diseases, while immune deficiency can lead to infectious diseases. We investigated the regulation of innate and adaptive immune cell activation by A...

BACKGROUND Coumarins are a major group of plant secondary metabolites that serves as defense compounds against pathogens. Although coumarins can be obtained from diverse plant sources, the use of microorganisms to synthesize them could be an alternative way to supply building blocks for the synthesis of diverse coumarin derivatives. RESULTS Constructs harboring two genes, F6'H (encoding ferul...

Several strategies have been proposed to control parasitic plants and these include biological control, the use of herbicides, suicidal germination or trap crops. In case sunflower, most effective solution is genetic resistance. Nevertheless, resistant cultivars followed by appearance new more virulent races parasite that overcome existing sources For this reason, it necessary increase our know...

Four new guaianolides, sinodielides A-D (1-4), were isolated from Sinodielsia yunnanensis WOLFF together with a known polyacetylene, falcarindiol, and two known coumarins, bergapten and scopoletin. Their structures were established by spectral and X-ray analyses.