are accustomed to scrutiny such as experimental protocol reviews, oversight on research conduct, and critiques provided during the peer-review publication process. We especially anticipate the post-publication period during which others attempt to reproduce, validate , and then build on our work. All this scrutiny is basic to establishing the credibility of our findings. We therefore should not...

A consideration of the absorption and metabolism of folic acid in human subjects is timely, owing to the recent recommendation by the UK Government’s Scientific Advisory Committee on Nutrition that a mandatory folic acid fortification programme be implemented in the UK. In this issue of the British Journal of Nutrition, Wright et al. take us through the processes of absorption and metabolism of...

Protein crystallography has been pivotal in defining the landscape of modern chemical biology. Visualizing the detailed architecture of proteins, nucleic acids and other biomolecules has shaped our molecular understanding of life and inspired countless mechanistic investigations. Given the sometimes extensive engineering required to generate crystallizable constructs, as well as an increased ap...

This position paper lists reasons why the results in software maintenance are so diicult to assess and use, proposes three possible countermeasures what and why, and shortly discusses the roadblocks. Note: This paper is written in a rather apodictic tone, but that is for brevity only. Why we have a mire of evidence When one dives into the literature on software maintenance , the amount of sugge...