INTRODUCTION A subgroup of voltage gated sodium channels including Nav1.8 are exclusively expressed on small diameter primary afferent neurons and are therefore believed to be integral to the neurotransmission of nociceptive pain. The present study examined whether local application of A-803467, a selective blocker of the Nav 1.8 sodium channel, can reduce nociceptive transmission from the join...

Hallux rigidus (HR) is the limitation of motion at the first metatarsophalangeal (MTP) joint, most commonly secondary to degenerative arthritis. Surgical options for treating HR include 2 general categories: joint salvage and joint destruction. A hybrid of techniques from the 2 categories has emerged: cartilage resurfacing, interpositional arthroplasty, and arthrodiastasis. These procedures add...

Osteoarthritis is the most common chronic musculoskeletal disease in dogs and cats. It is estimated approximately 60% of all dogs and close to 90% of aged adult cats are affected by this disease. 3 Osteoarthritis ( OA) is not a single disease entity but rather a disease process. It is a common final pathway for a failing synarthroidal or diarthroidal joint. It must be remembered the joint is an...

UNLABELLED Secondary arthrosis of the upper ankle joint (talocalcanean joint) is one of the most frequent forms of haemophilic arthropathy. It is a secondary form of arthrosis not only because of chronic synovitis and cartilage injury resulting from chronic recurrent intraarticular bleeds, but also due to the misalignment of the joint and abnormal joint stress. The consequences are manifest eve...

background and objectives: the cause and pathophysiology of rheumatoid arthritis has not been fully understood and an experimental model of this disease is essential for research on the problem. in this research study, establishment and histopathological changes of chronic arthritis due to intra-articular antigen injection was used as a model of experimental rheumatoid arthritis. materials and ...

In general RNA prediction problem includes genetic mapping, physical mapping and structure prediction. The ultimate goal of structure prediction is to obtain the three dimensional structure of bimolecules through computation. The key concept for solving the above mentioned problem is the appropriate representation of the biological structures. Even though, the problems that concern representati...

Prevotella bivia is an obligatory anaerobic, gram-negative rod, which often produces a detectable beta-lactamase. To date, there has been only 3 descriptions of septic arthritis secondary to this microorganism in a patients pre-existing sever joint disease like rheumatoid arthritis and osteoarthritis or after joint prosthesis. We are reporting the first case of septic arthritis due to Prevotell...

A novel method is presented for joint prediction of alignment and common secondary structures of two RNA sequences. The joint consideration of common secondary structures and alignment is accomplished by structural alignment over a search space defined by the newly introduced motif called matched helical regions. The matched helical region formulation generalizes previously employed constraints...

The use of PEG feeding has increased over the past decade. This article describes the development of a care pathway to support patients and maintain standards of care in PEG feeding.