Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60-70% of the drug molecules are insufficiently soluble in aqueous media and/or have very low permeability to allow for their adequate and reproducible absorption from the gastrointestinal tract (GIT) following oral administration. Formulation scientists have to adopt various strategies to...

Amaç: Kendiliğinden emülsifiye olan ilaç taşıyıcı sistemler (SEDDS), henüz tamamen aydınlatılmamış muazzam bir potansiyele sahiptir. Oral lipid uygulamasında suda çözünürlüğü düşük bileşiklerinin formülasyonunda kullanılabilirler ve bu bileşiklerle ilişkilendirilen birçok problemin üstesinden gelebilirler. SEDDS, küçük parçacık boyutuna, geniş yüzey alanına, yüksek kapsülleme etkinliğine yüküne...

The present study deals with formulation of a valsartan based Self emulsifying drug delivery system of a poorly water soluble drug. SEDDS are the isotropic mixtures of oil, surfactant, co surfactant and drug that form oil in water microemulsion when introduced into aqueous phase under gentle agitation. The present research work describes a Self Emulsifying Drug Delivery System (SEDDS) of valsar...

Introduction Oral drug delivery is a $35 billion dollar industry [1] and the most preferred way of drug administration. However, the oral route is not possible for 50% of currently marketed drug compounds due to their low solubility in water. Forty percent of prospective drugs coming out of discovery pipelines are lipophilic compounds, which leads to difficulty in achieving acceptable oral bioa...

Abstract Background Self-emulsifying system-based lipstick may prove to have the potential of enhancing moisturizing characteristics and delivering hydrophobic drug antifungal drugs for management lip fungal infection, especially candidiasis. In this study, self-emulsifying delivery system (SEDDs) ketoconazole was obtained using IPM (Oil), Tween 80 (surfactant), PEG 400 (co-surfactant). The med...

Approximately 40 % of newly discovered chemical entities have low solubility and possess bioavailability after oral administration. Lipid-based drug delivery systems (LBDDS) recently become very popular because their remarkable ability to deliver drugs with poor absorption using lipids as carriers. Self-emulsifying (SEDDS) are one type LBDDS employed for the incorporation hydrophobic drugs. SED...

Self emulsifying drug delivery systems (SEDDS) dikembangkan sebagai metode untuk meningkatkan kelarutan obat lipofilik seperti ibuprofen, serta absorpsi dan laju disolusi obat. Oleh karena itu penelitian ini bertujuan mengembangkan formulasi SEDDS ibuprofen yang memenuhi syarat secara farmasetik bioavailabilitas ibuprofen. Formula diperoleh dari uji optimasi formula pada berbagai konsentrasi mi...

Volume 5 • Issue 3 • 1000130 J Adv Chem Eng ISSN: 2090-4568 ACE an open access journal Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development Beatriz Zanchetta1,2, Marco Vinícius Chaud3 and Maria Helena Andrade Santana1,* 1Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, SP, Brazil 2Department of Research and ...

Recently, self-emulsifying drug delivery systems (SEDDS) have been developed as a method to deliver lipophilic drugs. Gelucire 44/14 is an excipient, from the lauroyl macrogolglycerides family, producing a fine oil-in-water emulsion when introduced into an aqueous phase under gentle agitation as SEDDS, improving thereby solubility of poorly water-soluble drugs and their bioavailability. The aim...