OBJECTIVE Cortical high-frequency oscillations (HFOs; 100-500 Hz) play a critical role in the pathogenesis of epilepsy; however, whether they represent a true epileptogenic process remains largely unknown. HFOs have been recorded in the human cortex but their network dynamics during the transitional period from interictal to ictal phase remain largely unknown. We sought to determine the high-fr...

background: lennox-gastaut syndrome (lgs) is an epileptic encephalopathy, characterized by drug-resistant multiple seizure types. the aim of this study was to determine if the adjunctive use of electroconvulsive therapy (ect) in patients with lgs and drug-resistant epilepsy is efficacious in decreasing their seizure frequency and also to investigate its safety and tolerability.   methods: this ...

OBJECTIVE To characterize changes in seizure frequency following felbamate withdrawal. DESIGN Nonrandomized, retrospective chart review of a case series. SETTING Epilepsy program specializing in adults with uncontrolled epilepsy. PATIENT POPULATION Forty-five ambulatory patients withdrawn from felbamate use. Patients were included if they had received felbamate for at least 1 month, were ...

We investigated the effect of galvanic skin response (GSR) biofeedback training on seizure frequency in patients with treatment-resistant epilepsy. Eighteen patients with drug-refractory epilepsy were randomly assigned either to an active GSR biofeedback group (n = 10) or to a sham control biofeedback group (n = 8). Biofeedback training significantly reduced seizure frequency in the active biof...

We analyzed surgical results of anterior callosotomy (AC) in 27 patients with intractable symptomatic generalized epilepsy or frontal lobe epilepsy. Excellent outcome (decrease in seizure frequency of greater than 80% or no seizure) was obtained in 59.3%, and 14.8% showed good outcome(decrease in seizure frequency of greater than 50%). There was no significant difference of the results between ...

The nonstationary and multicomponent nature of newborn EEG seizures tends to increase the complexity of the seizure detection problem. In dealing with this type of problems, time-frequency-based techniques were shown to outperform classical techniques. This paper presents a new time-frequency-based EEG seizure detection technique. The technique uses an estimate of the distribution function of t...