CLINICAL QUESTION Are selective serotonin reuptake inhibitors (SSRIs) associated with better recovery after stroke? BOTTOM LINE SSRIs may be associated with improved recovery after stroke, even in persons without depression. However, much of the evidence is of poor quality. Large, high-quality trials are needed to evaluate the validity of the current evidence and improve precision of estimate...

aim and background: considering the high frequency of anxiety and depressive symptoms in irritable bowel syndrome (ibs) patients, selective serotonin reuptake inhibitors (ssris) are recommended by some gastroenterologists for treatment. in this study, the efficacy of fluvoxamine on severity of symptoms and quality of life in ibs patients was assessed. methods and materials: a randomized, double...

In the past decades, selective serotonin reuptake inhibitors (SSRIs) have been shown to exert several immunological effects, such as reduced lymphocyte proliferation, alteration of cytokine secretion and induction of apoptosis. Based on these effects, SSRIs were proposed as drugs for the treatment of autoimmune pathologies and graft-versus-host disease. This review summarizes preclinical and cl...

Abstract Objectives Acute pain management in opioid users can be challenging the perioperative period. This study focuses on whether use of opioids increases sedation medication requirements patients undergoing port placement under moderate sedation. Materials and Methods A retrospective review was performed all between June 1, 2017, 30, 2019. Exclusion criteria included receiving general anest...

We report here a patient with major depressive disorder who experienced severe adverse effects after the administration of SSRIs (serotonin selective reuptake inhibitors) without improvement of his depressive symptoms. These adverse effects disappeared and his depressive symptoms improved after discontinuation of the SSRIs and the administration of tianeptine. The patient exhibited a low value ...

Since the introduction of monoamine oxidase inhibitors (MAOIs) in the 1950s, researchers have been searching for antidepressant agents with more favorable tolerability profiles. The introduction of selective serotonin reuptake inhibitors (SSRIs) in the late 1980s provided clinicians with a drug class featuring an improved tolerability profile as compared to MAOIs and tricyclic antidepressants (...

BACKGROUND Hirschsprung's disease is a rare condition caused by congenital malformation of the gastrointestinal tract affecting 1:5000 children. Not much is known about risk factors for development of Hirschsprung's disease. Two clinical cases of hirschsprung's disease led to an investigation of the association between maternal use of selective serotonin reuptake inhibitors (SSRIs) during pregn...

Hepatocellular carcinoma (HCC) is highly prevalent in Asia. Antidepressants have been associated with increase in hepatocellular carcinoma. This is the first Asian population-based study to evaluate the association between antidepressant use and risk of HCC. Based on Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study. A total of 49,998 cases w...

mood, one might predict that normal individuals treated with serotonin reuptake blockers would experience euFluoxetine and the Serotonin Model for Depression phoria, and that dietary serotonin depletion would inFluoxetine (a.k.a. Prozac) is well known for its ability to duce depression. In fact, these manipulations of serototreat clinical depression, one of the most prevalent of nin levels have...