The effect of selenium intake on the development of pancreatic cancer was investigated in female Syrian golden hamsters. Four-week-old hamsters were divided into 2 groups according to the selenium level in their drinking water and were fed a purified diet containing less than 0.05 ppm selenium. Starting 4 weeks later, groups received 10 s.c. injections at weekly intervals of N'-nitrosobis(2-oxo...

BACKGROUND Selenium, like other trace elements and antioxidant enzymes, is known as an antioxidant and immunomodulator trace element. Due to recent evidence for selenium deficiency in Behcet's syndrome, this study is to evaluate the correlation of serum selenium level with Behcet's disease (BD). MATERIALS This case-control study was conducted on 46 BD patients and 46 healthy controls in a rhe...

Purpose: To evaluate the correlation between the occurrence of age-related cataract (ARC) and the concentration of serum selenium. Methods: A study group included 95 cataract patients (36 men, 59 women), aged 56-89 years (72.4 ± 7.25), not suffering from other ocular diseases or systemic diseases with proven impact on the eye function or on blood levels of electrolytes. A control group consiste...

Effects of sodium selenite (SS) in offspring of broiler breeders has been reported, but the comparison between SS and different level of methionine on offspring has received limited, so this study was conducted to investigate sodium selenite and methionine effects on concentration of selenium in egg and serum of Iranian native broiler breeders. An experiment was conducted in 3 × 3 factorial exp...

BACKGROUND Copper and selenium are important trace elements in man. They function as antioxidants and play roles in oxido-reductase reactions. Several imported multivitamin preparations are given to our women during pregnancy and lactation to correct possible deficiencies. OBJECTIVE The aim of the study is to determine the serum level of these micronutrients (selenium and copper) in a cross s...

BACKGROUND Findings from animal models suggest that selenium supplementation improves glucose metabolism. OBJECTIVE To examine the effect of long-term selenium supplementation on the incidence of type 2 diabetes. DESIGN Secondary analysis of a randomized, double-blind, placebo-controlled trial. SETTING Areas of low selenium consumption of the eastern United States. PATIENTS 1202 persons...

chronic hepatitis b virus (hbv) infection is a major liver disease worldwide and its clinical manifestations are linked to immune response. the purpose of this study was to evaluate the relationship between selenium, copper, and zinc in comparison with transaminase level in chronic hbv patients. serum samples of the hbv infected patients were obtained from tooba medical center, sari, iran. sixt...

multiple sclerosis (ms) is an inflammatory demyelinating disease which the exact etiology is still are far to be clear. reasons for this autoimmune disease are unknown origin. the aim of present study was to evaluate serum levels of selenium in patient with ms compare to healthy subjects. a total of 46 subjects were enrolled in the study, sera of 23 ms cases and 23 healthy normal cohorts as con...

OBJECTIVE Higher selenium level has been hypothesized to have the potential to reduce the risk of cardiovascular diseases including dyslipidemia. However, results from previous studies are inconsistent. This study aims to determine the association between selenium level and dyslipidemia in elderly Chinese with relatively low selenium status. METHODS A cross-sectional study of 1859 participant...

Background: Poor response to various vaccines especially hepatitis B is common. The purpose of this study was to evaluate the effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.Methods: In this randomized clinical trial study, 62 insulin dependent diabetic patients were divided into case and control groups (e...