asperugo procumbents l. has been used in iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. the present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice.additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...

BACKGROUND Emergence agitation (EA) frequently occurs after desflurane anesthesia in children. Ketamine, because of its sedative and analgesic properties, might be useful for the management of separation anxiety and EA. We investigated the preventive effect of ketamine on separation anxiety and EA after desflurane anesthesia in children for brief ophthalmic surgery. METHODS Sixty children, ra...

in the present work sedative and hypnotic effects of aqueous extract of aloe vera in rats have been investigated. in order to evaluate the overall hypnotic effects of the aloe vera extract, open field and loss of righting reflex tests were primarily used. the sedative and hypnotic effects of the extract were then confirmed by detection of remarkable raise in the total sleeping time through anal...

upper endoscopy is a common procedure for the diagnosis and treatment of upper digestive tract diseases. the increasing number of pediatric gastrointestinal procedures has led to increasing attention on the safety and efficacy of medications used for sedation during the procedure. this randomized blinded interventional study was designed to compare the effect of oral midazolam with intravenous ...

Older people are frequent users of drugs with sedative properties. However, older people are susceptible to adverse drug events. Sedative drug use has been associated with impaired physical and cognitive function, an increased risk of falls and increased mortality. Sedative load refers to cumulative exposure to multiple drugs with sedative properties. This thesis aimed to investigate sedative l...

BACKGROUND In recent years, the number of prescriptions for sedative drugs has increased significantly, as has their long-term use. Moreover, sedative use is frequently initiated during hospital stays. OBJECTIVES This study aimed to describe new prescriptions of sedative drugs during hospital stays and evaluate their maintenance as discharge medication. METHODS This observational prospectiv...

BACKGROUND It is unknown whether sedative per se contributes to the postoperative sleep disturbance. Diagnostic upper gastrointestinal endoscopy (UGE) is a minimally invasive procedure which is not likely to cause tissue trauma and pain. The purpose of this study was to evaluate the sleep quality of patients undergoing routine (without sedative) diagnostic UGE or UGE with sedative, before, 1 we...

results there was no statistically significant difference between the mmse scores of the two groups before surgery (p = 0.6), but the mmse test conducted at the pacu revealed significantly better cognitive outcomes in the d group than in the r group in patients younger and older than 65 years (p = 0.03 and p = 0.0001, respectively). conclusions this study revealed that dexmedetomidine may be a ...