The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...

the regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using hplc methods. noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. the response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relatively i...

the effect of endogenous serotonin on long-term potentiation (ltp) in region cai was studied by blocking 5-ht2 receptors with ketanserin in rat hippocampal slices. such a block significantly en-hanced long-term potentiation of the cai population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. this implies that serotonin acts on 5-ht2 receptors in cai...

Since 2012, the World Health Organisation, US Food and Drug Administration, and recently Health Canada have released reports concluding that there is a potential risk of developing serotonin syndrome when 5-HT3 antagonists are used in combination with serotonergic drugs. These reports do not appear to have adequately considered current knowledge and understanding of serotonin toxicity (ST), hav...

Edward Blumenthal was affiliated with the University of California-San Diego at the time of publication.