BACKGROUND Studies on serum IgE levels during pregnancy are limited. OBJECTIVE To investigate the course of serum total IgE levels during pregnancy and postpartum. METHODS 159 pregnant subjects provided 218 serum samples during various stages of pregnancy and the postpartum period. Serum total IgE geometric means were compared at various trimesters and postpartum. In addition, the postpartu...

BACKGROUND Staphylococcus aureus may modify airway disease by inducing local formation of polyclonal IgE antibodies (abs), the role of which is unknown. METHODS Nasal mucosal tissue and serum was obtained from 12 allergic rhinitis (AR) and 14 nasal polyp (NP) subjects. Skin prick tests were performed, and total and specific IgE abs to inhalant allergens and enterotoxin B were determined in se...

The manifestations of allergic disorders are closely tied to the biologic effects of IgE activation with Ag. In immediate hypersensitivity reactions, IgE effector function requires prior binding to innate immune cells, primarily mast cells and basophils, with the blood acting as a reservoir for unbound IgE. As the severity of allergic disease is proportional to the size of this unbound IgE pool...

intradermal injection of autologous serum and plasma elicit a cutaneous reactivity in almost 45-60% of patients with chronic idiopathic urticaria (ciu).   this reactivity is associated with the presence of auto antibodies against ige or ige receptors. this study was carried out to compare the cutaneous reactivity of autologous serum and plasma skin tests in a series of patients with ciu for dia...

giardia lamblia is one of the most important intestinal parasites. the aim of this study was to measure serum levels of iga, ige, zinc, copper, vitamin b12 and folate in individuals with giardiasis in comparison to normal subjects.the study was carried out among 49 giardia positive and 39 age and sex matched healthy volunteers. examination of stool samples was done by direct wet smear and formo...

Atopic dermatitis (AD) has been sub-classified into extrinsic and intrinsic types according to the presence or not of allergen-specific IgE antibodies. Although total serum IgE levels are frequently elevated in AD, their potential to predict allergen-specific IgE (asIgE) has rare ly been studied. We investigated 103 children with AD and suspected allergen-specific sensitization. A thorough clin...

Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic understanding of allergic responses. We here characterize a novel soluble version of the IgE-binding alpha-chain of Fc-epsilon-RI (sFcεRI), the high affinity receptor for IgE. sFcεRI immunoprecipitates as a protein of ∼40 kDa and contains an intact IgE-binding site. In hu...

more allergens showed a higher incidence of raised IgE in serum (52%) than those reacting to only one allergen (23%), whereas only 1 of the 10 children in whom allergy investigation proved negative had raised serum IgE. In children where bronchial asthma was the only atopic disease, the incidence of raised serum IgE was low (14%), whereas high incidences (58-84%) were found when atopic dermatit...

more allergens showed a higher incidence of raised IgE in serum (52%) than those reacting to only one allergen (23%), whereas only 1 of the 10 children in whom allergy investigation proved negative had raised serum IgE. In children where bronchial asthma was the only atopic disease, the incidence of raised serum IgE was low (14%), whereas high incidences (58-84%) were found when atopic dermatit...