A new lactarane sesquiterpene, 1,2-dehydrolactarolide A (1), together with lactarorufin A (2), 3-O-ethyllactarolide A (3) and 3-O-ethyllactarolide B (4), was isolated from a mushroom of the Russulaceae family, Lactarius vellereus. Additionally, two lactarane sesquiterpenes, lactarorufin A (2) and lactarolide A (5) were isolated from L. subpiperatus. 1,2-Dehydrolactarolide A (1) showed promotion...

Sesquiterpene lactones (SLs) are a group of secondary metabolites that represent a diverse and unique class of natural products and are important constituent of essential oils, formed from head-to-tail condensation of three isoprene units and subsequent cyclization and oxidative transformation to produce a cis or trans-fused lactone. In this editorial we are going to focus on anticancer, anti-i...

A new sesquiterpene, 9-hydroxyfurodysinin-O-ethyl lactone, has been isolated from a New Caledonian Dysidea arenaria, along with three known compounds. The possible incorporation of the ethyl ether from the extraction solvent is discussed.

Studies aimed at a comparison of chemical, biomimetic (Gif system GoAgg(III))and enzymatic (CHMO) transformations of natural (+)-10beta,14-dihydroxy-allo-aromadendrane have led to preparation of an eight-member sesquiterpene lactone.

A 12-year-old hairy root culture of Cichorium intybus L., a callus culture of the plant as well as roots and leaves of a wild plant of chicory, and roots of two C. intybus L. var. sativum cultivars were examined in respect of their hydroxycinnamate and sesquiterpene lactone compositions and contents. Total phenolics and diphenylpicrylhydrazyl radical scavenging activity of the examined plant ti...

BACKGROUND Alzheimer's disease (AD) is characterized by a progressive memory loss that leads to a profound emotional disturbance in later stages. As no safe and effective drug is yet available for the treatment of AD, secondary metabolites from plants may be instrumental in meeting this challenge. Keeping in view this point we evaluated sesquiterpenes of medicinal plant Amberboa ramosa for thei...

Sesquiterpene lactones have long been used in traditional Chinese medicines to treat inflammatory diseases. Recently, sesquiterpene lactone family compounds have been recognized as potential anticancer agents. Thus, it is necessary to explore new sesquiterpene lactones and their antitumor mechanism for cancer treatments. In the present study, we have explored the potential anti-cancer activity ...