Severe traumatic brain injury is associated with both acute and delayed neuro- logical injury. Cerebral vasospasm is commonly associated with delayed neurological decline in aneurysmal subarachnoid hemorrhage patients. However, the role played by vasospasm in traumatic brain injury is less clear. Vasospasm occurs earlier, for a shorter duration, and often without significant neurological conseq...

Traumatic brain injury is a substantial cause ofmorbidity and mortality in the UK. An estimated 11 000 people per year sustain a severe traumatic brain injury, mostly between ages 15 and 29 years. Patients with severe traumatic brain injury have a high mortality rate (30-50%) and many survivors will have persistent severe neurological disability. Prompt identification and appropriate early mana...

OBJECTIVE To review novel therapeutic approaches in the treatment of severe traumatic brain injury. DESIGN Eighty-three studies were reviewed specific to the treatment of traumatic brain injury, in either experimental models or in patients. CONCLUSION Four therapeutic strategies appear to be the most promising approaches currently in clinical trials for severe traumatic brain injury: a) the...

PURPOSE OF REVIEW The aim of this article is to review the current status of protective effects of mild-to-moderate hypothermia on traumatic brain injury. RECENT FINDINGS More than 30 clinical studies have reported effects of therapeutic hypothermia on outcome of traumatic brain injury and cerebral ischemia. Only one clinical trial of short-term mild hypothermia did not show any effect in pat...

introduction guillain-barre syndrome (gbs) is an immune-mediated acute inflammatory disorder of the peripheral nervous system. infectious agents were usually accused of playing a role in the etiology of gbs. guillain-barre syndrome has rarely been reported following subdural and subarachnoid hemorrhage after head trauma. case presentation we report on a 63-year-old male patient presenting gbs f...

the incidence of traumatic brain injury (tbi) are annually increasing, developed tissue engineering methods could represent the definite remedies for patients with strongly injured central nervous system and have a great effect in the public healthcare cost. the current clinical treatments in tbi display several limitations. furthermore, several therapies, coming from neural tissue engineering ...

the sex hormone progesterone has been shown to improve outcomes in animal models and two early-phase trials involving patients with traumatic brain injury (tbi). the aim of this clinical study was to assess the effect of progesterone on the improvement of neurologic outcome in patients with diffuse and acute tbi. a prospective, randomized, double-blind trial of progesterone was conducted in our...

traumatic brain injury (tbi) results from a sudden and external physical impact to the head, and often leads to motor and cognitive impairment. using tissue engineering strategies, we aimed to review aspects of extra cellular matrix (ecm) based scaffold that could be delivered to the injured brain. the ecm is produced intracellularly and secreted to form a dense network of proteins and glycans,...

catatonia is a syndrome that can be treated with electroconvulsive therapy (ect). hence, onset of catatonia during treatment of patients with ect is not expected. in this manuscript, a schizoaffective disorder patient with a positive history of traumatic brain injury and no consumption of benzodiazepines is being reported, who became catatonic during ect.