Circulating tumor cells (CTCs) are the primary targets of cancer treatment as they cause distal metastasis. However, how CTCs response to exercise-induced high shear stress is largely unknown. To study the effects of hemodynamic microenvironment on CTCs, we designed a microfluidic circulatory system that produces exercise relevant shear stresses. We explore the effects of shear stresses on brea...

a 5th order shear deformation theory considering transverse shear deformation effect as well as transverse normal strain deformation effect is presented for static flexure   analysis of simply supported isotropic plate. the assumed displacement field accounts for non-linear variation of in-plane displacements as well as transverse displacement through the plate thickness. the condition of zero ...

geometric and material nonlinear behavior of slender webs in i-column girders having stocky flanges under the action of combined lateral and axial loads is investigated. interaction curves corresponding to the application of compressive and shear loads at buckling and ultimate stages for both web plates and column sections are plotted. in addition, the effects of flange and web slenderness rati...

the effects of cementation and the physical properties of grains on the shear behavior of grouted sands are investigated in this paper. the consolidated-undrained triaxial shear behavior of three grouted carbonate sands with different physical properties, including particle size distribution, particle shape and void ratio, was studied. two sands were obtained from the north shores of the persia...

OBJECTIVE Bone morphogenetic protein 4 (BMP-4) is a transforming growth factor beta family member cytokine that exerts proinflammatory effects on the endothelium and is likely to play a role in atherogenesis. Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown. METHODS AND RESULTS We fo...

Although studies on RC beams under shear have a history record of more than 100 years, many important&#10issues in this context still remain that have evaded attention. The aim of the current study is to study a number of these less investigated aspects of the behavior of RC beams under shear. For this purpose, and based on the modified compression field theory, a computer program has been writ...

Although studies on RC beams under shear have a history record of more than 100 years, many important issues in this context still remain that have evaded attention. The aim of the current study is to study a number of these less investigated aspects of the behavior of RC beams under shear. For this purpose, and based on the modified compression field theory, a computer program has been writte...

The epithelial sodium channel (ENaC) is regulated by multiple extracellular stimuli, including shear stress. Previous studies suggest that the extracellular finger domains of ENaC α and γ subunits contain allosteric regulatory modules. However, the role of the finger domain in the shear stress response is unknown. We examined whether mutations of specific residues in the finger domain of the α ...