BACKGROUND An increasing number of neuroscientific studies gain insights by focusing on differences in functional connectivity-between groups, individuals, temporal windows, or task conditions. We found using simulations that additional insights into such differences can be gained by forgoing variance normalization, a procedure used by most functional connectivity measures. Simulations indicate...

A hybrid (signal-symbol) approach for detecting significant changes in imagery uses a signal-based change detection algorithm followed by a symbol-based change interpreter. The change detection algorithm is based on a linear prediction model which uses small patches from a reference image to locally model the corresponding areas in a newly acquired image, and vice versa. Areas that cannot be ac...

patients with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (melas) present with recurrent and partially reversible neurological deficits. lesions of melas classically cause a signal change in both the grey and white matter, predominantly in the occipital and parietal lobes. these lesions mimic infarction. here, we reported a case of melas with rare neuroimaging finding...