background: cholera toxin b subunit (ctb) has been extensively considered as an immunogenic and adjuvant protein, but its yield of expression is not satisfactory in many studies. the aim of this study was to compare the expression of native and mutant recombinant ctb (rctb) in pqe vector. methods: ctxb fragment from vibrio cholerae o1 atcc14035 containing the substitution of mutant ctxb for ami...

Abstract BACKGROUND: Mutations of NFkB1 are a known cause inborn errors immunity resulting in immunodeficiency due to the role as transcriptional regulator immunomodulating proteins. We present patient with diagnosis common variable (CVID), cytopenias massive splenomegaly, and nodular regenerative hyperplasia liver. Our proband, 22-year-old male, presents clinical picture immunodeficiency, has ...

Fig. S1: Mutation matrices used in this study. (a) JAK2-negative myeloproliferative neoplasm: single-cell exome sequencing of 58 tumor cells, 18 mutation sites selected for importance out of 712 SNVs [1]. Estimated error rates: 0.4309 for allelic dropout and 6.04 × 10−6 for false discovery, 45% missing data points. The mutation matrix is taken from [2]. Color coding of matrix cells: blue hetero...