BACKGROUND Wound healing is a complex process, with many potential factors that can delay or complicate healing. Bacterial infection is one of the most dangerous complications once the skin barrier is destroyed. The search for optimal treatment of chronic and infected wounds is an ongoing challenge for healthcare professionals. METHODS This article discusses recent findings in the field of wo...

Previous investigations demonstrated that pyruvate protects human keratinocytes against cell damage stemming from exposure to ultraviolet B (UVB) radiation. This study endeavoured to elucidate the protective capacity of aromatic pyruvates (e.g., phenylpyruvate (PPyr), 4-hydroxyphenylpyruvate (HPPyr), and indole-3-pyruvate (IPyr)) against UVB-induced injury to skin cells, both in vitro and in vi...

Ultraviolet (UV) radiation from the sun is widely considered as a major cause of human skin photoaging and skin cancer. Granzyme B (GrB) and perforin (PFN) are two proteins contained in granules and implicated in one of the mechanisms by which cytotoxic lymphocytes and natural killer cells exert their cytotoxicity against virus-infected, alloreactive, or transformed cells. The distribution of G...

Skin wounds are one of the most common injuries for human body; they can lead to an infection and cause tissue necrosis even life-threatening injuries. Therefore, it is urgent task develop skin scaffold materials meet various needs restoring skin’s structural integrity. In this research, kaolinite nanotubes silver nanowires co-doped silk fibroin gelatin composite porous fiber films were fabrica...

Background. Programs of preclinical safety studies the health care products depend on regulatory status investigated products. The classification such products, in particular suppositories for rectal and vaginal use, is a critical step developing tactics their biological evaluation. Adaptation evaluation methods medical devices based combination biologically active substances, as well results u...

Introduction: Gadolinium based contrast agents have been reported to induce nephrogenic systemic fibrosis (NSF) in patients with impaired renal function. Skin fibrosis is a characteristic symptom while the mechanism of causing NSF is unclear. In this study, we investigated the cytotoxicty Gd(III)-based contrast agents, including Omniscan®, Mutihance® and ProHance®, to normal rat skin fibroblast...

Methods Alcohol proportion and bactericidal agents (e.g. CHG (chlorhexidine gluconate), BAC (benzalkonium chloride), PHMB and OCT (Octenidine)) were compared to determine suitability for surgical hand antisepsis. PHMB-containing handrub was then tested in accordance with European Norm (EN). To further evaluate the hand antiseptics or bactericidal agents, their cytotoxicity was investigated with...