A 47-year-old man visited to the hospital complaining of an illness for which he was prescribed metformin 1000mg daily with other drug combination such as Ramipril 10mg once daily, Simvastatin 40mg at night, Aspirin 75mg once daily. The patient had been recently diagnosed for diabetes mellitus. The (RBS) random blood sugar level reported at that time was 271mg/dL. The physician had prescribed m...

The drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a severe adverse drug-induced reaction which includes a severe skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytes) and internal organ involvement. The most frequently reported drug was anticonvulsants. The diagnosis of DRESS syndrome is challenging because the pattern of cutaneous eru...

Background Drug reaction with eosinophilia and systemic symptom (DRESS) is a severe drug-induced cutaneous reaction with visceral involvement and blood abnormalities associated with reactivations of herpes-virus family i.e., EBV, HHV-6, HHV-7 and CMV. Recently, we demonstrated that the immune response in DRESS, previously thought to be directed only against drug components, is also mediated by ...

background: the reporting of adverse drug reactions (adrs) by nurses in hospitals is very important.aims: this study was aimed at investigating the impact of an educational intervention to improve adr reporting and whethertrained nurses had better knowledge, attitude, and practice toward adr reporting. materials and methods: a total of 300 nurses in a tertiary care teaching hospital in tehran, ...

background: s. alopecuroides, z. officinale and m. officinalis are used traditionally in the treatment of pain. objective: to evaluate the plants effects in the rat formalin test and their activity on the opioid receptors. methods: each rat was placed individually in a cage for 30 min to get acclimated. then 0.05 ml of 10% formalin was injected subcutaneously into the dorsal surface of the righ...

thrombolytic agents are among the medications that are used widely for the treatment of thromboembolic disorders and myocardial infarction (mi). despite the world-wide availability of newer specific agents, streptokinase (sk) is still the most frequently used medication from this class in iran. hence we conducted this study to review the adverse reactions to this medication which were reported ...

PATIENT Female, 75 FINAL DIAGNOSIS: Hypertensive crisis with multi organ failure Symptoms: Anemia • general weakness • hypokalemia • nausea • tachycardia MEDICATION - Clinical Procedure: - Specialty: Cardiology. OBJECTIVE Unexpected drug reaction. BACKGROUND Skin reactions are common adverse drug reactions and may include angioedema, erythroderma, Stevens-Johnson syndrome, and toxic epide...

Methods and results A 75-year old male suffering from erysipelas received simultaneous treatment with oral clindamycin and i.v. penicillin G, which later was switched to oral penicillin. After eight days of antibiotic therapy an erythematous maculopapular exanthema developed on his trunk and extremities. Treatment was changed to cefuroxime, topical steroids initiated and the skin rash slowly va...

[b] Abstract Objective.[/b] The aim of the study was an assessment of direct costs of patients hospitalised for for skin adverse drug reactions during 2002-2012 in the Department of Dermatology at the Military Institute of Medicine (Ministry of Defence) in Warsaw. The analysis was carried out from the perspectives of the public payer and service provider. [b]Materials and method. [/b]The retros...