Cancer is a deadly disease wherein the immune system inefficient, resulting in malignant tumors that metastasize. An active and robust body’s natural defense. Research efforts continue exploring alternative immunotherapies to fight cancer. This communication proposes non-infectious vaccines hyper-allergenic skin creams starve through metabolic interference.

This study was aimed to investigate the effects of cream containing Ficus carica L. fruit (Fig) extract on various skin parameters such as skin melanin, erythema, moisture content, trans-epidermal water loss and sebum. For this purpose, formulation with 4% concentrated extract of F. carica fruit and base without extract were developed. Base served as a control. Both base and formulation were ap...

: Hyper-IgE syndrome is a primary immunodeficiency marked by abnormalities in the coordination of cell-cell signaling with the potential to affect TH17 cell, B cell, and neutrophil responses. Clinical manifestations include recurrent skin and lung infections, serum IgE elevation, connective tissue repair and development alterations, and the propensity for vascular abnormalities and tumor develo...

Ehlers-Danlos syndrome is a rarely encountered connective tissue disorder characterized by skin hyper-elasticity, joint hyper-flexibility, and vasculature fragility. We report a 41-year-old female presenting with scalp swelling following minor head trauma. The patient presented with a large cephalohematoma that despite compressive measures and Factor IX administration continued to progress, nec...

Effects of histamine per se along with its specific agonists and antagonists were studied on the skin melanophores of Hemidactylus flaviviridis to study the role of histamine receptors in pigmentation. Histamine and 2-methyl histamine induced powerful melanin aggregation effects, leading to paling of the skin through stimulation of H1 receptors. On the other hand, 4-methyl histamine, a specific...

We describe 8 children with hyper-IgE syndrome who had papulopustular eruption on the face and scalp in the first year of life. Seven of the 8 patients had persistent peripheral eosinophilia and 3 had leukocytosis noted before diagnosis. Skin biopsy specimens in 6 patients revealed spongiosis and perivascular dermatitis and/or folliculitis with a predominance of eosinophils. Two patients had bo...

Hypothalamic-pituitary-adrenal (HPA) axis hormones and their receptors expressed in the skin are known to function locally, but how these hormones affect the maintenance of skin homeostasis or the pathogenesis of skin diseases is not fully understood. We comprehensively reviewed the distribution and function of the central and peripheral HPA axis in various stress-related skin diseases. Previou...

This study was performed to investigate the different methods of treating hyper granulation tissue on experimentally induced wounds in equine limbs. Wounds were induced by removal of a skin patch and subcutaneous tissue for about 5-7 cm width and 6-8 cm in length from the dorsal and lateral aspect of the fore and hind limbs below the carpal and tarsal joints. The wounds were left open without t...

According to clinical protocols, skin diseases are quanti ed by dermatologists throughout a treatment period, and then a statistical test on these measures allows to evaluate a treatment e cacy. The rst step of this process it to classify pathological interest areas. This task is challenging due to the high variability of the images in one clinical data set. In this report, we rst review algori...