OBJECTIVE Although many clinical studies on skip lymphatic metastasis in non-small cell lung cancer have been reported, the risk factors for skip lymphatic metastasis are still controversy and debatable. This study investigated, by multivariate logistic regression analysis, the clinical features of skip metastasis to mediastinal lymph nodes (N(2)) in non-small cell lung cancer (NSCLC) patients....

A changing world needs schools that adapt to changes and support their students thrive. The related developments are moderated, guided, also implemented by principals. To do this, they need the of staff, but administrative from system. In Germany, system's is based on a link between management leadership through clear task descriptions. following text analyzes interviews with six school princip...

BACKGROUND The removal of introns from pre-mRNA is carried out by a large macromolecular machine called the spliceosome. The peptidyl-prolyl cis/trans isomerase PPIL1 is a component of the human spliceosome and binds to the spliceosomal SKIP protein via a binding site distinct from its active site. PRINCIPAL FINDINGS Here, we have studied the PPIL1 protein and its interaction with SKIP bioche...

Section 20.6.6.2 [util.smartptr.shared], paragraph 1, talks about the class template shared_ptr storing a pointer, but does not introduce explicit the pointer owned by the shared pointer (with the corresponding object of some type Y that is being owned). This makes it hard for the reader to realize that this is different from the pointer stored by this same shared pointer (the address of the ob...

OBJECTIVE To reveal the incidence and clinical significance of mediastinal nodal metastases without N1-station nodal metastases ('skip-N2 metastases') in non-small cell lung cancer (NSCLC). METHODS A total of 450 NSCLC patients who underwent tumor resection with a systemic mediastinal nodal dissection were retrospectively reviewed. p53 status and proliferative activity represented as prolifer...

Human sirtuin 1 (SIRT1) is a NAD(+)-dependent deacetylase that participates in cell death/survival, senescence and metabolism. Although its substrates are well characterized, no direct regulators have been defined. Here, we show that SIRT1 associates with SKI-interacting protein (SKIP) and modulates its activity as a coactivator of retinoic acid receptor (RAR). Binding assays indicated that SKI...

Lysosomes move bidirectionally on microtubules, and this motility can be stimulated by overexpression of the small GTPase Arl8. By using affinity chromatography, we find that Arl8-GTP binds to the soluble protein SKIP (SifA and kinesin-interacting protein, aka PLEKHM2). SKIP was originally identified as a target of the Salmonella effector protein SifA and found to bind the light chain of kinesi...