BACKGROUND The process of discovering new drugs is a lengthy, time-consuming and expensive process. Modern day drug discovery relies heavily on the rapid identification of novel 'targets', usually proteins that can be modulated by small molecule drugs to cure or minimise the effects of a disease. Of the 20,000 proteins currently reported as comprising the human proteome, just under a quarter of...

The linear Induction motor, first conceived in the 19 century, could present a viable solution to the problem of quick and efficient transportation. However the performance of Single Sided Linear Induction Motor (SLIM) is severely degraded by ‘end effects’ and ‘transverse edge effects’. The present work is an attempt to investigate the magnetic flux distribution within the air gap and other reg...

Three studies show that product packaging shape serves as a cue that communicates healthiness of food products. Inspired by embodiment accounts, we show that packaging that simulates a slim body shape acts as a symbolic cue for product healthiness (e.g., low in calories), as opposed to packaging that simulates a wide body shape. Furthermore, we show that the effect of slim package shape on cons...

Structures for Lossless Ion Manipulation (SLIM) represent a novel class of ion optical devices based upon electrodes patterned on planar surfaces, and relying on a combined action of radiofrequency and DC electric fields and specific buffer gas density conditions. Initial experimental studies have demonstrated the feasibility of the SLIM concept. This report offers an in-depth consideration of ...

A comparative study is carried out between a semi-empirical low-latitude ionospheric model (SLIM). including calculated 01 630 nm airglow emission intensities predicted by the SLIM model, with ionospheric and r>I 630 nm airglow measurements carried out at Cachoeira Paulista (22.7”S, 45.O”W; geomag. 11.9”S), Brazil. A long series of regular measurements of ionospheric F-region peak electron dens...

| Multicasting enables applications to scale to a large number of users without overloading the network and server resources. With the advent of multimedia applications , the focus of multicasting research has shifted from minimizing the overall cost of the multicast tree to nding one which supports the QoS requirements of the underlying multimedia application. Finding such a tree, however, is ...

Transcription factor (TF) binding to DNA is crucial for transcriptional regulation. There are multiple methods for mapping such binding. These methods balance between input requirements, spatial resolution, and compatibility with high-throughput automation. Here, we describe SLIM-ChIP (short-fragment-enriched, low-input, indexed MNase ChIP), which combines enzymatic fragmentation of chromatin a...

A finite lattice L is called slim if no three join-irreducible elements of L form an antichain. Slim semimodular lattices play the main role in G. Czédli and E.T. Schmidt [5], where lattice theory is applied to a purely group theoretical problem. Here we develop a unique matrix representation for these lattices.

OBJECTIVE The aim of the present study was to explore the effects of exposure to slim images and diet-related products in commercials on actual food intake in relation to dietary restraint. DESIGN An experimental design was used, in which food intake was measured in 124 female students who watched either a sad or a neutral movie on television, which was interrupted by either commercials featu...

Sparse Linear Methods (SLIM) are state-of-the-art recommendation approaches based on matrix factorization, which rely on a regularized l1-norm and l2-norm optimization –an alternative optimization problem to the traditional Frobenious norm. Although they have shown outstanding performance in Top-N recommendation, existent works have not yet analyzed some inherent assumptions that can have an im...