amyloid pathology is associated with fibril aggregation of different proteins which results in the progressive damage of affected organs. it is strongly believed that specific small molecules interfere with fibrillation by interacting with the amyloidogenic proteins. we had previously reported the strong and long-term inhibition of fibrillation of hen egg white lysozyme (hewl) by cuminum cyminu...

in view of potential biological activities of small molecule polyamides, we synthesized some novel n-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamide (7a,b), and n-(2-(1-benzyl-2-(alkylthio) -1h-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamides (8a,b) as antitumor agents. the antitumor activity of compounds 7a,b and 8a,b was studied at concent...

Small molecule microarrays have recently been used to identify ligands for several proteins, and several themes regarding screening strategies and limitations have emerged. In this review, some of the technical issues related to the manufacture and screening of small molecule microarrays, as well as prospects for small molecule microarrays in several areas of drug discovery and chemistry, are d...

The use of dad (and bian) ligands in the stabilization main-group complexes, particular metal–metal-bonded compounds, as well small molecule reactivity these (low-valent) metal is summarized.

Small-molecule microarrays composed of tens of thousands of distinct synthetic molecules, natural products, and their combinations/modifications provide a high-throughput platform for studying protein-ligand interactions. Immobilization of small molecule compounds on solid supports remains a challenge as widely varied small molecules generally lack unique chemical groups that readily react with...