PURPOSE The aim of this study was to show that novel photodynamic therapy (PDT) sensitizers can be activated by two-photon absorption in the near-IR region of the spectrum and to show, for the first time, that such activation can lead to tumor regressions at significant tissue depth. These experiments also evaluated effects of high-energy femtosecond pulsed laser irradiation on normal tissues a...

The molecular target(s) cooperating with proteasome inhibition in multiple myeloma (MM) remain unknown. We therefore measured proliferation in MM cells transfected with 13 984 small interfering RNAs in the absence or presence of increasing concentrations of bortezomib. We identified 37 genes, which when silenced, are not directly cytotoxic but do synergistically potentiate the growth inhibitory...

It was hypothesized that both sensitizers and repressers exceed those individuals falling in the middle of the distribution with respect to frequency and severity of illnesses. The 1st investigation utilized 2 independent samples of undergraduates (N= 173 and 319) who were given the Repression-Sensitization (R-S) Scale and a health survey. Though there was no support for the curvilinearity hypo...

Although the advantages and disadvantages of asymmetrical thiazolidinediones as insulin-sensitizers have been well-studied, relevance symmetry asymmetry for biguanides has scarcely explored. Regarding symmetrical molecules, only one thiazolidinedione no evaluated proposed an antihyperglycemic agent treating type 2 diabetes. Since molecular structure defines physicochemical, pharmacological, tox...

Novel quinoxaline-based organic sensitizers using vertical (RC-21) and horizontal (RC-22) conjugation between an electron-donating triphenylamine unit and electron-accepting quinoxaline unit have been synthesized and used for dye-sensitized solar cells (DSSCs), leading to the relatively high power conversion efficiencies of 3.30 and 5.56% for RC-21 and RC-22, respectively. This result indicates...

Donor–π–acceptor (D–π–A) porphyrin based photo-sensitizers are extensively utilized in dye sensitized solar cells (DSSCs).

Ss were 40 male patients hospitalized on a psychiatric ward and defined as maladjusted and 40 male patients hospitalized on a medical-surgical ward and defined as adjusted. The medical and psychiatric groups were each composed of equal subgroups of low-competence repressers, low-competence sensitizers, high-competence repressers, and high-competence sensitizers. All Ss completed a social desira...

The putative role played by insulin sensitizers in modulating adipose tissue lipolysis in the fasting state was evaluated in obese conscious Zucker rats treated with troglitazone or beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) and compared with nontreated lean and obese animals. The rates of appearance (R(a)) of glycerol and free fatty acid (FFA), primary intra-adipose reesterificatio...

Pointsource photodynamic therapy (PSPDT) is a newly developed fiber optic method aimed at the delivery of photosensitizer, light and oxygen to a diseased site. Because of a need for developing photosensitizers with desirable properties for PSPDT, we have carried out a synthetic, photophysical and phototoxicity study on a series of PEGylated sensitizers. Chlorin and pheophorbide sensitizers were...