SHP (small heterodimer partner) is a well-known NR (nuclear receptor) co-regulator. In the present study, we have identified a new SHP-interacting protein, termed SMILE (SHP-interacting leucine zipper protein), which was previously designated as ZF (Zhangfei) via a yeast two-hybrid system. We have determined that the SMILE gene generates two isoforms [SMILE-L (long isoform of SMILE) and SMILE-S...

background:   materials and methods:   determine possible significances in the relation of smile line to angle occlusion class, overbite and overjet and arch form. a p   results:   conclusion:   and important relation between some occlusal parameters and smile design, which must be considered. within the limitations of such studies, it might be concluded that there is a significant chi-square t...

Aims: To assess the influence of profession, treatment experience, age and gender on the perception of smile aesthetics with different buccal corridors and smile arcs, and to identify the threshold where buccal corridor space becomes aesthetically displeasing. Study Design: A questionnaire-based descriptive study on the assessment of attractiveness ratings by laypeople. Place and Duration of St...

OBJECTIVES The study assessed the impact of facial height on attractiveness of smile, in association with the maxillary gingival display. This research was performed by dental professionals and laypersons. MATERIALS AND METHODS Frontal extraoral photographs were captured for both short and long faces. The photographs were modified using software for image-processing and three rater groups (or...

PURPOSE To compare dry eye after small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK (FS-LASIK) for correcting myopia. METHODS CENTRAL, Embase and PubMed were searched in November 2016. All randomized controlled trials (RCTs) and prospective cohorts that compared dry eye after SMILE with FS-LASIK were selected. RESULTS Five cohorts and one RCT were identified fo...

OBJECTIVE This study aimed to quantitatively assess the relationship of smile esthetic variables with various types of malocclusion, and identify the cephalometric factors affecting smile measurements. METHODS This retrospective study included 106 patients who were treated with retention at the orthodontic department of Taipei Medical University Hospital. Hard-tissue variables were measured u...

The role of a glucagon/cAMP-dependent protein kinase-inducible coactivator PGC-1α signaling pathway is well characterized in hepatic gluconeogenesis. However, an opposing protein kinase B (PKB)/Akt-inducible corepressor signaling pathway is unknown. A previous report has demonstrated that small heterodimer partner-interacting leucine zipper protein (SMILE) regulates the nuclear receptors and tr...

OBJECTIVE To test the null hypothesis that there is no clinically significant difference between the post-orthodontic treatment images of smiles of subjects captured by clinical photography and the smiles of the same subjects obtained from digital video clips. MATERIALS AND METHODS Clinical photographs and digital video captures were obtained from 48 orthodontically treated patients. An updat...

INTRODUCTION Esthetics and attractiveness of the smile is one of the major demands in contemporary orthodontic treatment. In order to improve a smile design, it is necessary to record "posed smile" as an intentional, non-pressure, static, natural and reproducible smile. The record then should be analyzed to determine its characteristics. In this study, we intended to design and introduce a soft...

OBJECTIVE The images of smiling people are omnipresent in marketing. Frequency, smile characteristics, context of the smile and target audience in newspaper advertisements were points of interest of this study. MATERIAL AND METHODS Four examiners analyzed 600 advertisements from 46 European magazines and newspapers by using content and framing analysis. Twenty items of the analysis form the p...