Some cancer cells evade chemotherapy by expressing cell membrane pumps to expel toxins. One such pump is the P-glycoprotein, which exports the widely used chemotherapy compound Taxol as it passes through the membrane. To counter P-glycoprotein efflux, Elena Dubikovskaya et al. modified Taxol’s structure, attaching a peptide that alters the mechanism by which the compound enters cells. The new c...

We describe two stochastic network interdiction models for thwarting nuclear smuggling. In the first model, the smuggler travels through a transportation network on a path that maximizes the probability of evading detection, and the interdictor installs radiation sensors to minimize that evasion probability. The problem is stochastic because the smuggler’s origin-destination pair is known only ...

A 42-year-old African male was brought by the police to the emergency department under suspicion of drug smuggling by body-packing. Plain abdominal radiograph showed multiple foreign bodies within the gastrointestinal tract. Contrast-enhanced abdominal CT confirmed the findings, and the patient admitted to have swallowed "balls" of hashish. Body-packing is a recognized method of smuggling drugs...

Internal British American Tobacco (BAT) documents 1 have been explicit about the knowledge of cigarette smuggling into Vietnam. In one document , Vietnam Status Report (12 May 1995), it was stated: " Cigarette imports were banned 6 years ago. Smuggled sales into Vietnam are currently estimated at approximately 7 bn [bil-lion] p.a. although prior to a crack-down in 1990 (when all smuggling was v...