Soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP)-25 is a neuronal SNARE protein essential for neurotransmitter release from presynaptic terminals. Three palmitoylated SNAP-25 family proteins: SNAP-25a, SNAP-25b, and SNAP-23, are expressed in the brain, but little is known about their distributions and functions. In the present study, we generated specific antibodies to distin...

The SNARE complex, consisting of synaptobrevin, syntaxin, and SNAP-25, is essential for calcium-triggered exocytosis in neurosecretory cells. Little is known, however, about how developmentally regulated isoforms and other cognate SNARE components regulate vesicular fusion. To address this question, we examined neuroexocytosis from chromaffin cells of Snap25 null mice rescued by the two splice ...

AbstractObjective To examine the mediating effects of food resource management skills (FRM) on relationship between participation in a Supplemental Nutrition Assistance Program Education (SNAP-Ed) nutrition education program and diet quality. Design Secondary analysis data from propensity score-matched sample participants (n = 396) nonparticipants 111) SNAP-Ed ...

We adopted a person–organization (P–O) fit framework to examine applicant attraction to an organization in the context of Web-based recruitment. A total of 121 undergraduate business students participated in a two-stage study first by completing a paper-and-pencil survey and second, by visiting a fictitious recruitment Web site in which the researchers manipulated the fit feedback information p...

1 Anscombe’s term for such knowledge in Intention is “practical knowledge”. However, I have avoided that term as I wish to defend the idea that agents have a distinctive non-observational knowledge of their actions without being committed to her claims about the existence of a kind of knowledge with a reverse direction of fit from ordinary knowledge. 2 The idea originates in English speaking ph...

The synaptic protein SNAP-25 is an important component of the neurotransmitter release machinery, although its precise function is still unknown. Genetic analysis of other synaptic proteins has yielded valuable information on their role in synaptic transmission. In this study, we performed a mutagenesis screen to identify new SNAP-25 alleles that fail to complement our previously isolated reces...

N-ethylmaleimide-sensitive fusion protein (NSF) and alpha-SNAP play key roles in vesicular traffic through the secretory pathway. In this study, NH2- and COOH-terminal truncation mutants of alpha-SNAP were assayed for ability to bind NSF and stimulate its ATPase activity. Deletion of up to 160 NH2-terminal amino acids had little effect on the ability of alpha-SNAP to stimulate the ATPase activi...

It has recently been widely argued that all consciousness is perceptual, including the conscious experience of action. This paper argues that there can be a conscious component of the experience of action that is not perceptual. The argument is based on Searle’s concept of “direction of fit” and the conditions of satisfaction of an intention. The conditions of satisfaction of an intention diffe...

February 19, 2015 Version 1.4.7 Date 2013-03-04 Author Peter Frommolt Maintainer Peter Frommolt Title Inferences for biand trifactorial trial designs Depends mvtnorm,multcomp,lattice,graphics,methods,Rcpp (>= 0.8.8) LinkingTo Rcpp Description This package makes global and multiple inferences for given biand trifactorial clinical trial designs using bootstrap method...