Due to the high variance in available protocols on iodide-131 ((131)I) ablation in rodents, we set out to establish an effective method to generate a thyroid-ablated mouse model that allows the application of the sodium iodide symporter (NIS) as a reporter gene without interference with thyroidal NIS. We tested a range of (131)I doses with and without prestimulation of thyroidal radioiodide upt...

BACKGROUND High-intensity focused ultrasound (HIFU) allows to inflict intracorporal thermal lesions without penetrating the skin or damaging the surrounding tissue. This analysis intends to assess the magnitude of HIFU-induced ablations within benign thyroid nodules using scintigraphic imaging with (99m)Tc. METHODS Ten cold, hot, or indifferent nodules were treated using multiple pulses of HI...

1 Fadime Demir1, Taner Erselcan2, Bülent Turgut3, Zekiye Hasbek3, Perihan Kelkit4, Ayşegül Özdal5, Serdar Savaş Gül6, Pelin Duman7 1Department of Nüclear Medicine, Elazığ Researc and Educational Hospital, Elazığ, 2Nüclear Medicine, Muğla Sıtkı Koçman University, Faculty of Medicine, Muğla, 3Nüclear Medicine, Cumhuriyet University, Faculty of Medicine, Sivas, 4Department of Nüclear Medicine, Siv...

BACKGROUND Gastric cancers have poor overall survival despite recent advancements in early detection methods, endoscopic resection techniques, and chemotherapy treatments. Vaccinia viral therapy has had promising therapeutic potential for various cancers and has a great safety profile. We investigated the therapeutic efficacy of a novel genetically-engineered vaccinia virus carrying the human s...

Objective: The purpose of this study was to investigate if an octadecyl (18C) minicolumn could be applied successfully for quality control of 99mTc exametazime (HMPAO). Methods: The 18C column system using saline eluent was validated against the Whatman 17 method in calculating the percent radiochemical purity of 99mTc-HMPAO. The behavior of 99mTc-pertechnetate (TcO4) and hydrolyzed-reduced 99m...

UNLABELLED For noninvasive monitoring of cellular status by dual reporters, a dual membrane protein reporter system was developed and its in vivo applicability was examined. Human sodium iodide symporter (hNIS) and mutant dopamine D(2) receptor (D(2)R) transgenes were chosen considering their complementarity. METHODS pIRES-hNIS/D(2)R containing NIS and D(2)R linked with an internal ribosomal ...

This article examines the production of metastable technetium-99 (Tc-99m), the world’s most important radiopharmaceutical, focusing on reliability of supply and risks of nuclear terrorism. Only four producers manufactured about 95 percent of the world’s Tc-99m; a closure of any of them could cause worldwide shortfalls. Moreover, all four employ highly enriched uranium in their production proces...

HYPOTHESIS Preoperative parathyroid and thyroid imaging using technetium Tc 99m sestamibi scintigraphy-single-photon emission computed tomography (Tc 99m MIBI SPECT) and technetium Tc 99m sodium pertechnetate, respectively, in patients with parathyroid adenomas and concomitant multinodular goiters enables the selection of those suitable for minimally invasive radio-guided surgery. DESIGN One ...

INTRODUCTION Variceal haemorrhage is a potentially life-threatening complication in cirrhotic patients. Identification of patients at high risk for bleeding is particularly important. The aim of this study was to determine the clinical usefulness of per-rectal portal scintigraphy (PPS) in the evaluation of the severity of portal hypertension in cirrhotic patients, in terms of correlation betwee...

OBJECTIVE To investigate in vivo and in humans the mechanisms and kinetics of vagina-to-uterus distribution. DESIGN Controlled clinical study. SETTING Volunteers in an academic research environment. PATIENT(S) Six postmenopausal women undergoing transabdominal hysterectomy were selected. INTERVENTION(S) Women received 0.2 mL of (99m)Tc-pertechnetate vaginally. In three patients the cerv...