Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...

objective(s): alzheimer's disease (ad) is a neurodegenerative disorder in elderly patients. decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. improvement and potentiation of the cholinergic system could be beneficial for treatment of the ad. acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylc...

The organocatalytic enantioselective trifluoromethylthiolation of oxindoles employing N-(trifluoromethylthio)phthalimide as a stable, easy to handle CF3S-source has been developed. Optically active products with a quaternary stereogenic center bearing a CF3S-group are obtained in good yields and with good to excellent enantioselectivities.

The title N-benzyl-phthalimide derivative, C16H13NO3, consists of two planar moieties, viz. the phthalimide system (r.m.s. deviation = 0.007 Å) and the phenyl ring, which make a dihedral angle of 84.7 (6)°. The meth-oxy group is almost coplanar with the phathalimide ring, as shown by the C-C-O-C torsion angle of -171.5 (2)°. In the crystal, the mol-ecules are self-assembled via non-classical C-...

In the title mol-ecule, C(17)H(15)NO(5)S, the dihedral angle between the essentially planar atoms of the tosyl moiety (the S atom and the seven tolyl C atoms) and the phthalimide moiety is 6.089 (3)°. The mol-ecule is folded about the ethyl-ene bridge, adopting a staggered conformation such that the benzene ring of the tosyl group and the five-membered ring of the phthalimide moiety have a face...

Direct and sensitized excitation of 3-(N-phthalimido)adamantane-1-carboxylic acid (1) leads to the population of the triplet state that, in the presence of a base, decarboxylates, giving N-(1-adamantyl)phthalimide (2) cleanly and efficiently (Φ = 0.11). The radical initially formed by decarboxylation adds regiospecifically to electron deficient alkenes, whereas radical addition was not observed...

Composite nanoparticles were synthesized by eco-friendly hydrothermal process and characterized by different spectroscopic techniques. All the spectroscopic techniques suggested the synthesis of well crystalline optically active composite nanoparticles with average diameter of ∼ 30 nm. The synthesized nanoparticles were applied for the development of chemical sensor which was fabricated by coat...

In the title compound, C(16)H(13)NO(2), the phthalimide and benzene ring systems form a dihedral angle of 77.2 (1)°.