The subthalamic nucleus (STN) belongs to the basal ganglia and is the current target for the surgical treatment of neurological and psychiatric disorders such as Parkinson's Disease (PD) and obsessive compulsive disorders (OCD), but also a proposed site for the treatment of addiction. It is therefore very important to understand its functions in order to anticipate and prevent possible side-eff...

Background: Nitazoxanide (NTZ) is a broad spectrum antimicrobial agent with poor aqueous solubility and low bioavailability. Thus, the generation of new solid forms NTZ relevant to improve its unfavorable properties. The present study deals application mechanochemistry for preparation alternate NTZ, using saccharine (SAC) as coformer. Methods: NTZ-SAC mixtures were prepared by neat liquid-assis...

"Beauty is truth, truth beauty" to the poet. But a biologist is bound, I think, to regard beauty—at least man-made beauty—as something closer to a lie. A lie, admittedly, of a unique kind, but a kind to which both men and animals are specially vulnerable. If I give a hungry dog a solution of saccharine it will lap it up; if I show a cock robin a bundle of feathers with a red patch on its unders...

Restricted feeding schedules (RF) in which daily access to food is limited to a few hours each day can entrain the rhythms of expression of circadian clock genes in the brain and periphery in rodents. The critical factors mediating the effect of RF on rhythms of clock gene expression are unknown. Previously, we demonstrated that daytime RF shifts the phase of expression of the clock protein, Pe...

The objective of the present study was to compare the efficacy of functional endoscopic dilatation sinus surgery (FEDS) with functional endoscopic sinus surgery (FESS) in treatment of chronic rhinosinusitis in patients who failed medical therapy. We enrolled 24 patients suffering with chronic rhinosinusitis, who failed medical treatment and were proceeding to surgery, in a prospective, randomiz...