sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. the aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. these group...

Epilepsy is defined as the occurrence of two or more unprovoked seizures. The cumulative life time incidence is 3%, and more than half start in childhood. Antiepileptic valproic acid is used in most of the cases as 1 st line therapy. The objective of the study was to evaluate the effect of valproate on thyroid hormone, insulin and prolactin in childhood epilepsy. A hospital-based, analytical cr...

Kolaviron (KV) is a biflavonoid isolate mixture of defatted Garcinia kola seed extract patented for treatment hepatic disorders and inflammation-related conditions. The clinical experimental-based reports on liver impairment valproic acid, front-line synthetic drug used in the epilepsy gained public attention. Therefore, mitigative effect perturbed redox status genotoxicity caused by sodium val...

A simple, precise, and accurate stability indicating gas chromatographic method has been developed and validated for assay of Magnesium Valproate. The Chromatographic system used to perform development and validation of this assay method consisted of Shimadzu 2014 G.C. with Flame Ionization Detector and a manual injector. The method was validated for specificity, linearity, precision, accuracy,...

The complete spectrum of neuropsychiatric effects SARS-CoV-2 acute respiratory distress syndrome has yet to be fully appreciated, particularly in intubated patients. Manifestations including delirium and catatonia need considered COVID-19 Medications known exhibit neuroprotective effects, like valproate, can assist agitation related sedative withdrawal during extubation. This case series report...

migraine is a common and incapacitating neurologic disorder manifesting with episodic moderate to a severe headache and other symptoms such as photophobia, phonophobia, nausea, and vomiting. triptans and ergot compounds have been used as treatment options for an acute migraine headache for many years. triptans are considered the first line of treatment in patients with moderate to a severe migr...

This study evaluated the protective effect of ellagic acid on sodium valproate-induced sperm abnormalities in male Wistar rats. A total of 30 rats were grouped into five groups, each having 6 animals. Vehicle, sodium valproate (400 mg/kg) and ellagic acid (10, 25, 50 mg/kg) were given orally from day 1 to day 7, and ellagic acid was continued for 3 more days. On day fourteen, animals were sacri...

BACKGROUND Prevention of bladder cancer recurrence is a central challenge in the management of this highly prevalent disease. The histone deacetylase inhibitor valproic acid (sodium valproate) has anti-angiogenic properties and has been shown to decrease bladder cancer growth in model systems. We have previously shown reduced expression of thrombospondin-1 in a mouse model and in human bladder ...

1. Abstract 2. Basic principle for corporal drug movement 2.1. Membrane transporters 2.2. Cardiac output distribution 2.3. Gastrointestinal-blood cycling 2.4. Drug distribution throughout the splanchnic organs 2.5. Efflux transportation, blood flow fraction, and drug recycling 3. Phenytoin 3.1. Michaelis-Menten consideration 3.2. Hepatic, intestinal, and renal contribution to phenytoin clearanc...

Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls. In patients taking enzyme-inducing drugs, uric acid levels were found to be lower than in those under valproate sodium. In addition, uric acid concentrations showed a negative correlation with duration of therapy ...